Description
The Bisfluorophenyl Advancement
Product Details Table
| Specification | Details |
|---|---|
| Brand | BIOSYNLAB Research Compounds |
| Product Name | Fladrafinil (CRL-40,941) Eugeroic Research Capsules |
| IUPAC Name | 2-[Bis(4-fluorophenyl)methylsulfinyl]-N-hydroxyacetamide |
| CAS Number | 90212-80-9 |
| Synonyms | CRL-40,941, Fluorafinil, Bisfluoroadrafinil |
| Molecular Formula | C₁₅H₁₃F₂NO₃S |
| Molecular Weight | 325.33 g/mol |
| Purity Grade | ≥99% (LC-MS verified) |
| Formulation | 50mg per vegan capsule (60 capsules per container) |
| Chemical Class | Eugeroic; Benzhydryl sulfinyl acetamide derivative |
| Mechanism | Dopamine transporter inhibition, histamine release, orexin activation |
| Appearance | White to off-white crystalline powder in plant-based HPMC capsules |
| Packaging | Industrial-grade amber PET, nitrogen-flushed, 60-count |
| Storage | 2-8°C refrigerated, light-protected, moisture-free |
| Batch Analysis | COA, LC-MS chromatogram available |
| Origin | GMP-certified synthesis facility |
| Shipping | Cold-chain logistics, customs documentation included |
Next-Generation Eugeroics: The Bisfluorophenyl Advancement
Are you investigating novel wakefulness-promoting mechanisms, dopaminergic neurotransmission, or histaminergic modulation for narcolepsy and shift-work disorder research? BIOSYNLAB delivers pharmaceutical-grade Fladrafinil capsules—synthesized to exacting specifications for neuropharmacological research, sleep medicine laboratories, and cognitive enhancement studies across the USA, Europe, and United Kingdom markets.
Fladrafinil (CRL-40,941, Fluorafinil) represents a structural evolution of the eugeroic pharmacophore, featuring dual 4-fluorophenyl substitutions that enhance lipophilicity and blood-brain barrier penetration compared to Adrafinil and Modafinil. Developed by Laboratoire Lafon (France) as a developmental successor to Modafinil, this bisfluorinated benzhydryl sulfinyl acetamide has emerged as a critical reference compound for investigating wakefulness circuits, dopamine reuptake inhibition, and histaminergic neurotransmission.
Our synthesis protocol employs controlled oxidation of the corresponding sulfide precursor, delivering the pharmacologically active sulfoxide configuration with chiral purity and batch-to-batch consistency that meets the demanding standards of receptor pharmacology, sleep research, and behavioral neuroscience.
Chemical Structure & Mechanism of Action
Structural Classification: Fladrafinil belongs to the eugeroic chemical family featuring:
- Bis(4-fluorophenyl)methyl core: Lipophilic diaryl system enhancing CNS penetration
- Sulfinyl (S=O) linker: Oxidized thioether conferring metabolic stability
- Hydroxyacetamide tail: Hydrophilic moiety for receptor interaction and solubility
- Fluorine substitutions: Electron-withdrawing groups modifying pharmacokinetics
Pharmacological Profile:
Primary Mechanism: Dopaminergic Modulation
- Dopamine transporter (DAT) inhibition: Reduced dopamine reuptake, increased synaptic DA
- D1/D2 receptor indirect agonism: Elevated extracellular dopamine levels
- Norepinephrine transporter (NET) inhibition: Enhanced noradrenergic tone
Secondary Mechanisms
- Histamine release: Activation of tuberomammillary nucleus histaminergic neurons
- Orexin (hypocretin) activation: Stimulation of lateral hypothalamic orexin neurons
- GABA-A antagonism: Reduced inhibitory neurotransmission (mild)
- Glutamate enhancement: Increased excitatory neurotransmission
Industrial Applications & Research Implementations
Sleep Medicine & Circadian Research
Fladrafinil serves as a critical tool compound for:
- Narcolepsy models – Orexin-deficient and orexin-intact wakefulness studies
- Shift-work disorder – Circadian rhythm disruption and recovery protocols
- Sleep deprivation research – Cognitive performance under restricted sleep
- Hypersomnia studies – Excessive daytime sleepiness mechanisms
Cognitive Pharmacology
- Executive function enhancement – Working memory and attention studies
- Motivation and reward – Dopaminergic incentive salience research
- Fatigue countermeasures – Sustained attention and vigilance tasks
- Cognitive aging – Age-related cognitive decline interventions
Neuropharmacological Research
- DAT binding assays – Radioligand competition and autoradiography
- Histamine H3 receptor studies – Inverse agonism and wakefulness mechanisms
- Orexin receptor research – OX1R and OX2R activation profiles
- Microdialysis studies – Extracellular monoamine monitoring
Pharmaceutical Development
- Eugeroic SAR studies – Structure-activity relationship optimization
- Prodrug development – Bioavailability and metabolic stability enhancement
- Formulation science – Extended-release and transdermal delivery systems
- Drug interaction profiling – CYP450 enzyme studies
Synthesis Methodology & Quality Assurance
Manufacturing Protocol:
- Starting Material: Bis(4-fluorophenyl)methanethiol precursor
- Alkylation: Reaction with chloroacetic acid derivative
- Amidation: Conversion to hydroxyacetamide (N-hydroxy functionality)
- Oxidation: Controlled oxidation to sulfoxide (mCPBA or sodium periodate)
- Purification: Column chromatography and recrystallization
- Drying: Vacuum desiccation to <0.5% residual moisture
- Micronization: Controlled particle size for optimal dissolution
- Encapsulation: 50mg precision dosing in vegan HPMC capsules
Analytical Verification:
- LC-MS Purity: ≥99% (UV detection at 254nm)
- Mass Spectrometry: Molecular ion confirmation (m/z 326.1 [M+H]+)
- NMR Spectroscopy: ¹H-NMR and ¹³C-NMR structural validation
- Chiral Analysis: Sulfoxide stereochemistry confirmation
- Residual Solvents: GC-MS verification (ICH Q3C compliance)
- Heavy Metals: ICP-MS screening (Pb, Cd, Hg, As <10 ppm)
- Water Content: Karl Fischer titration (<0.5%)
Commercial & Transactional Keywords
Primary Search Terms:
- Buy fladrafinil capsules online Europe
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- Fluorafinil 50mg wholesale Germany
- Eugeroic research chemical supplier
- Order bisfluoroadrafinil Amsterdam
- Wakefulness promoting agent Europe
- Dopamine transporter inhibitor research
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Responsible Consumption & Research Disclaimer
⚠️ BIOSYNLAB Responsible Use Policy:
This product is sold strictly for research, laboratory analysis, and industrial applications only. Not intended for human consumption, therapeutic use, or clinical administration without appropriate regulatory approval and clinical trial authorization.
- For in vitro and in vivo research purposes only
- Handle exclusively within certified laboratory environments
- Utilize appropriate engineering controls (fume hoods, laminar flow)
- Personal protective equipment required: nitrile gloves, safety goggles, lab coat
- Review Material Safety Data Sheet (MSDS) prior to handling
- Comply with FDA, EMA, and local regulations regarding research compounds
Regulatory Notice: Fladrafinil (CRL-40,941) is not approved for human consumption in the USA, EU, or UK. It is a developmental compound that was never marketed. Related compounds (Modafinil, Armodafinil) are prescription-only medications in many jurisdictions. This research-grade product is not intended for human use. Purchasers assume full responsibility for compliance with applicable research chemical regulations and institutional biosafety protocols. BIOSYNLAB provides this compound exclusively to qualified research entities with appropriate documentation.
Storage & Stability: Product maintains chemical integrity for 24 months when stored at 2-8°C in original packaging. Protect from light and moisture.
Why Research Facilities Choose BIOSYNLAB
- Synthetic Excellence: GMP-grade eugeroic synthesis with >99% purity
- Documentation Package: Comprehensive COA, MSDS, NMR spectra, LC-MS chromatograms
- Batch Consistency: Statistical process control (SPC) monitoring
- Regulatory Compliance: REACH-registered, customs-bonded warehousing
- Technical Support: PhD-level consultation on dopaminergic and histaminergic pharmacology
- Secure Logistics: Temperature-monitored, insurance-covered international shipping
- Custom Formulations: Bulk synthesis and custom capsule manufacturing available
Ready to advance your eugeroic and wakefulness research with premium-grade Fladrafinil? Contact BIOSYNLAB for bulk pricing, custom synthesis inquiries, or technical specifications. Our neuropharmacology team provides complimentary consultation on DAT binding assays, sleep-wake cycle studies, and cognitive enhancement protocol development.
