Description
BIOSYNLAB Vinpocetine Capsules – 15mg Pharmaceutical Grade
Product Details Table
| Specification | Details |
|---|---|
| Brand | BIOSYNLAB Research Compounds |
| Product Name | Vinpocetine (AY-27255) Synthetic Alkaloid Capsules |
| IUPAC Name | Ethyl (3α,16α)-14,15-dihydro-14-hydroxyeburnamenine-14-carboxylate |
| CAS Number | 42971-09-5 |
| Synonyms | AY-27255, RGH-4405, Cavinton, Ethyl Apovincaminate |
| Molecular Formula | C₂₂H₂₆N₂O₂ |
| Molecular Weight | 350.46 g/mol |
| Purity Grade | ≥99.0% (EP/USP standard, HPLC verified) |
| Formulation | 15mg per vegetarian capsule |
| Appearance | White to off-white crystalline powder in clear HPMC capsules |
| Melting Point | 149-153°C |
| Specific Rotation | [α]²⁰D +115° to +120° (C=2, pyridine) |
| Mechanism | PDE1 inhibitor, cerebral vasodilator, calcium channel modulator |
| Packaging | Amber borosilicate vials, argon-purged, desiccated |
| Storage | 2-8°C refrigerated, light-protected, moisture-free |
| Batch Analysis | COA, HPLC chromatogram, optical rotation data |
| Origin | GMP-certified synthesis facility |
| Shipping | Cold-chain logistics, customs documentation included |
Cerebrovascular Pharmacology: The Synthetic Alkaloid Standard
Are you investigating cerebral blood flow modulation, phosphodiesterase inhibition, or neuroprotective mechanisms in ischemic conditions? BIOSYNLAB delivers pharmaceutical-grade Vinpocetine capsules—synthesized to exacting specifications for neurovascular research, stroke modeling, and cognitive pharmacology laboratories across the USA, Europe, and United Kingdom markets.
Vinpocetine (ethyl apovincaminate, AY-27255) represents the semisynthetic evolution of the vincamine alkaloid, optimized for enhanced bioavailability and targeted cerebrovascular activity. Originally developed by the Richter Gedeon pharmaceutical laboratories, this synthetic derivative has emerged as a critical reference compound for investigating cyclic nucleotide phosphodiesterases, cerebral metabolism, and neuronal protection under hypoxic and ischemic stress.
Our synthesis protocol employs stereoselective esterification of apovincaminic acid, delivering the pharmacologically active (3α,16α)-cis configuration with chiral purity exceeding 99%. Each batch undergoes rigorous analytical verification to ensure compliance with European Pharmacopoeia (EP) and United States Pharmacopeia (USP) standards.
Chemical Structure & Mechanism of Action
Structural Classification: Vinpocetine is a synthetic vinca alkaloid derivative featuring:
- Eburnamine skeleton: Characteristic indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine core
- Ethyl ester moiety: Enhanced lipophilicity and blood-brain barrier penetration
- Cis-stereochemistry: (3α,16α)-configuration conferring optimal receptor binding
Pharmacological Profile:
Primary Mechanism: PDE1 Inhibition
- Target: Calcium/calmodulin-dependent phosphodiesterase 1 (PDE1)
- Ki value: 14 μM (competitive inhibition)
- Effect: Elevated intracellular cAMP and cGMP levels
- Downstream: Enhanced cerebral blood flow, reduced vascular resistance
Secondary Mechanisms
- Sodium channel modulation: Voltage-gated Na⁺ channel blockade
- Mitochondrial protection: Enhanced glucose and oxygen utilization
- Antioxidant activity: Scavenging of hydroxyl radicals
- Anti-inflammatory: Inhibition of NF-κB activation and cytokine release
Industrial Applications & Research Implementations
Cerebrovascular Research
Vinpocetine serves as a critical tool compound for:
- Cerebral blood flow studies – PET and SPECT imaging applications
- Ischemic stroke modeling – Middle cerebral artery occlusion (MCAO) protocols
- Hypoxia-ischemia research – Neonatal encephalopathy models
- Vascular dementia studies – Chronic hypoperfusion mechanisms
Neuropharmacological Applications
- Cognitive enhancement research – Memory and learning mechanism studies
- Neuroprotection assays – Glutamate excitotoxicity and oxidative stress models
- Aging brain research – Cerebral metabolic rate of oxygen (CMRO₂) investigations
Pharmaceutical Development
- Lead compound optimization for cerebrovascular disorders
- Formulation development for intravenous and oral delivery
- Bioequivalence studies for generic development
- Drug-drug interaction profiling
Analytical Chemistry
- HPLC reference standard for PDE inhibitor quantification
- Chiral chromatography standard for enantiomeric purity assessment
- Mass spectrometry calibration material
Synthesis Methodology & Quality Assurance
Manufacturing Protocol:
- Starting Material: Vincamine alkaloid extraction from Vinca minor
- Hydrolysis: Conversion to apovincaminic acid
- Esterification: Stereoselective ethyl ester formation
- Resolution: Chiral chromatographic separation of cis/trans isomers
- Crystallization: Recrystallization from ethanol-water system
- Drying: Vacuum desiccation to <0.5% residual moisture
- Micronization: Controlled particle size reduction
- Encapsulation: 15mg precision dosing in vegetarian HPMC capsules
Analytical Verification:
- HPLC Purity: ≥99.0% (UV detection at 280nm)
- Chiral Purity: e.e. >99% (cis-configuration confirmed)
- Optical Rotation: [α]²⁰D +115° to +120° (C=2, pyridine)
- Melting Point: 149-153°C (DSC thermogram)
- Residual Solvents: GC-MS (ICH Q3C compliance)
- Heavy Metals: ICP-MS (Pb, Cd, Hg, As <10 ppm)
- Water Content: Karl Fischer titration (<0.5%)
Commercial & Transactional Keywords
Primary Search Terms:
- Buy vinpocetine capsules online Europe
- Purchase AY-27255 UK supplier
- RGH-4405 wholesale Germany
- PDE1 inhibitor research chemical
- Order vinpocetine 15mg Amsterdam
- Cerebral vasodilator supplier Europe
- Buy ethyl apovincaminate online
- Cavinton research grade
Responsible Consumption & Research Disclaimer
⚠️ BIOSYNLAB Responsible Use Policy:
This product is sold strictly for research, laboratory analysis, and industrial applications only. Not intended for human consumption, therapeutic use, or clinical administration without appropriate regulatory approval.
- For in vitro and in vivo research purposes only
- Handle exclusively within certified laboratory environments
- Utilize appropriate engineering controls (fume hoods, laminar flow)
- Personal protective equipment required: nitrile gloves, safety goggles, lab coat
- Review Material Safety Data Sheet (MSDS) prior to handling
- Comply with DEA, FDA, EMA, and local regulations regarding synthetic alkaloids
Regulatory Notice: Vinpocetine is regulated as a prescription medication in many jurisdictions and as a dietary supplement in others. In the EU, it is classified as a medicinal product requiring marketing authorization. This research-grade product is not intended for human consumption. Purchasers assume full responsibility for compliance with applicable controlled substance analog laws, pharmaceutical regulations, and institutional biosafety protocols. BIOSYNLAB provides this compound exclusively to qualified research entities with appropriate documentation and institutional approval.
Storage & Stability: Product maintains chemical integrity for 24 months when stored at 2-8°C under inert atmosphere. Protect from light and moisture. Do not freeze.
Why Research Facilities Choose BIOSYNLAB
- Pharmaceutical-Grade Synthesis: EP/USP-compliant manufacturing standards
- Stereochemical Purity: Guaranteed cis-configuration with chiral verification
- Documentation Package: Comprehensive COA, MSDS, NMR spectra, HPLC chromatograms
- Batch Consistency: Rigorous statistical process control (SPC) monitoring
- Regulatory Compliance: REACH-registered, customs-bonded warehousing
- Technical Support: PhD-level consultation on cerebrovascular pharmacology
- Secure Logistics: Temperature-monitored, insurance-covered international shipping
Ready to advance your cerebrovascular research with premium-grade Vinpocetine? Contact BIOSYNLAB for bulk pricing, custom synthesis inquiries, or technical specifications. Our medicinal chemistry team provides complimentary consultation on PDE inhibition assays, cerebral blood flow measurement protocols, and neuroprotective mechanism studies.
