Description
Premium S-4 (Andarine) Capsules – Industrial Grade Research Chemical
Product Details Table
| Attribute | Specification |
|---|---|
| Brand | BioSynLab Research Compounds |
| Product Name | S-4 (Andarine) |
| Synonyms | Andarine, GTX-007, S4, Acetamidoxolutamide |
| CAS Number | 401900-40-1 |
| Molecular Formula | C₁₉H₁₈F₃N₃O₆ |
| Molecular Weight | 441.36 g/mol |
| Chemical Class | Selective Androgen Receptor Modulator (SARM) – First Generation |
| Purity | ≥99.0% (HPLC Verified) |
| Dosage Form | Hard Gelatin Capsules |
| Unit Dose | 25mg, 50mg, or 75mg (custom available) |
| Capsule Size | Size 3 (25mg), Size 1 (50mg), Size 0 (75mg) |
| Capsule Color | Yellow opaque (25mg), Orange/White (50mg), Orange (75mg) |
| Fill Weight | 150-350mg (API + excipients) |
| Excipients | Microcrystalline cellulose, Magnesium stearate, Silicon dioxide |
| Packaging | HDPE bottles (30, 60, 90 count) or blister packs |
| Storage | 2-25°C, Desiccated, Light Protected |
| Shelf Life | 24 months (sealed container) |
| Documentation | COA, HPLC, NMR, MS, MSDS, Stability Data |
| Shipping | Ambient Temperature, Discrete |
| Origin | EU/GMP Certified Laboratory |
S-4 (Andarine) Capsules | First-Generation SARM for Androgen Receptor Research | BioSynLab
BioSynLab presents pharmaceutical-grade S-4 (Andarine) in convenient capsule formulation for advanced androgen receptor research, partial agonist studies, and comparative SARM pharmacology. As one of the first non-steroidal SARMs developed, Andarine serves as a critical historical reference compound for investigating tissue-selective androgen signaling, partial agonist mechanisms, and off-target receptor interactions in laboratory settings.
Chemical Architecture & First-Generation SARM Design
S-4 (Andarine, GTX-007) represents the aryl propionamide class of first-generation SARMs, featuring a distinctive structural scaffold that established the foundation for subsequent SARM development:
Structural Features:
- Aryl Propionamide Core: Non-steroidal backbone with anabolic activity
- Cyanonitro Substitution: Electron-withdrawing groups optimizing receptor binding
- Trifluoromethyl Group: Metabolic stability enhancement
- Hydroxyl Moiety: Hydrogen bonding capability with AR ligand-binding domain
Mechanism of Action:
- Androgen Receptor Partial Agonist: Lower intrinsic activity than full agonists (testosterone, DHT)
- Tissue-Selective Activity: Anabolic effects in muscle and bone with reduced prostate stimulation
- Binding Affinity: Ki ~4 nM (moderate affinity vs. newer SARMs)
- Metabolism: Extensive first-pass hepatic metabolism to active metabolites
Physicochemical Properties:
- Molecular weight: 441.36 g/mol (higher than LGD-4033)
- Calculated LogP: 2.8 (moderate lipophilicity)
- pKa: Non-ionizable (neutral molecule)
- Melting point: 70-75°C (amorphous solid tendency)
- Chirality: Single enantiomer (chiral center in propionamide)
Capsule Formulation & Pharmaceutical Engineering
Our S-4 capsules utilize precision formulation technology:
Excipient Composition:
- Active Pharmaceutical Ingredient: S-4 – 25mg, 50mg, or 75mg
- Diluent: Microcrystalline cellulose (Avicel PH-102) – 100-250mg
- Glidant: Silicon dioxide (Aerosil) – 2-5mg
- Lubricant: Magnesium stearate – 2-3mg
Capsule Specifications:
| Strength | Capsule Size | Fill Weight | Color Code |
|---|---|---|---|
| 25mg | Size 3 | ~150mg | Yellow opaque |
| 50mg | Size 1 | ~220mg | Orange/White |
| 75mg | Size 0 | ~280mg | Orange |
Quality Attributes:
- Content uniformity: RSD <6% (USP <905>)
- Weight variation: Meets USP <905> criteria
- Disintegration: <30 minutes (USP <701>)
- Dissolution: >75% in 45 minutes
Packaging Options:
- HDPE bottles: 30, 60, 90 count with desiccant canister
- Blister packs: 10 capsules per sheet, child-resistant
- Bulk packaging: 500, 1000 count for institutional orders
Analytical Characterization & Quality Verification
Each BioSynLab S-4 batch undergoes comprehensive analytical profiling:
Chromatographic Analysis:
- HPLC-UV (220nm): ≥99.0% purity
- Chiral HPLC: Enantiomeric purity >99% ee
- Related substances: <1.0% total impurities
- Residual solvents: Meets ICH Q3C
Mass Spectrometry:
- LC-MS/MS: [M+H]⁺ at m/z 442.1, characteristic fragmentation
- High-Resolution MS: Exact mass <5 ppm deviation
Nuclear Magnetic Resonance (NMR):
- ¹H NMR (500MHz, DMSO-d₆):
- Aromatic protons: δ 6.8-8.0 (m, 8H)
- Propionamide CH: δ 3.45 (m, 1H)
- Hydroxyl: δ 5.95 (br s, 1H)
- CF₃: δ Not observed (¹⁹F NMR)
- ¹⁹F NMR: Single signal at δ -61.8 ppm
- ¹³C NMR (125MHz): 19 distinct carbon signals
- FTIR: O-H (3400 cm⁻¹), C=O (1660, 1680 cm⁻¹), C-F (1120 cm⁻¹), NO₂ (1550 cm⁻¹)
Physical Testing:
- Water content: <0.5% (Karl Fischer)
- Heavy metals: <10 ppm (ICP-MS)
- Specific rotation: [α]²⁰D = -15° to -19° (c=1, methanol)
- Residue on ignition: <0.1%
Research Applications & Scientific Significance
S-4 capsules serve critical functions in multiple research disciplines:
Androgen Receptor Pharmacology:
- Partial agonist characterization (intrinsic activity studies)
- Tissue-selective gene expression (muscle vs. prostate)
- Coactivator recruitment differences (vs. full agonists)
- Historical SARM comparison (first-gen vs. second-gen)
Off-Target Research:
- Ocular receptor binding (vision side effect mechanism)
- Retinal pigment epithelium studies
- Night vision impairment modeling
- Selectivity improvement research (driving development of newer SARMs)
Musculoskeletal Research:
- Muscle atrophy models (cancer, disuse, aging)
- Bone density studies (osteoporosis models)
- Fracture healing research
- Comparison with LGD-4033/MK-2866
Metabolic Studies:
- Body composition analysis
- Lipid profile effects (HDL/LDL changes)
- Insulin sensitivity research
- Energy expenditure quantification
Historical & Comparative Research:
- First-generation SARM benchmark
- Structure-activity evolution (S-4 → Ostarine → Ligandrol)
- Clinical discontinuation rationale studies (vision effects)
- Regulatory development impact
Global Distribution & Discrete Procurement
BioSynLab provides secure, compliant distribution:
Packaging Specifications:
- Primary: Hard gelatin capsules in HDPE bottles or blister packs
- Secondary: Tamper-evident seals, desiccant chambers
- Tertiary: Discrete unmarked shipping containers
Shipping Options:
- Standard: Ambient temperature, 5-7 days
- Express: Tracked courier, 2-3 days
- Discrete: No product identifiers, generic return addresses
Service Coverage:
United Kingdom: London, Manchester, Birmingham, Leeds, Glasgow, Liverpool, Sheffield, Bristol, Edinburgh, Cardiff, Belfast, Nottingham, Leicester.
European Union: Berlin, Hamburg, Munich, Cologne, Frankfurt, Amsterdam, Rotterdam, Paris, Lyon, Barcelona, Madrid, Rome, Milan, Vienna, Brussels, Prague, Warsaw.
North America: New York, Los Angeles, Chicago, Houston, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Toronto, Vancouver.
