{"id":223,"date":"2026-06-07T23:40:29","date_gmt":"2026-06-07T23:40:29","guid":{"rendered":"https:\/\/biosynlab.com\/?post_type=product&p=223"},"modified":"2026-07-21T14:31:45","modified_gmt":"2026-07-21T14:31:45","slug":"buy-u-47700-powder","status":"publish","type":"product","link":"https:\/\/www.biosynlab.com\/?product=buy-u-47700-powder","title":{"rendered":"Buy U-47700 Powder"},"content":{"rendered":"

Premium U-47700 Powder: Industrial Grade Supply for Advanced Research Applications<\/h1>\n

 <\/p>\n

U-47700 (trans-3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide)<\/strong>\u00a0represents a synthetic opioid compound originally developed by Upjohn Pharmaceuticals in the 1970s as part of a series of kappa-opioid receptor selective agonists. As a structural analog of AH-7921 with distinct pharmacological properties, U-47700 has emerged as a critical reference standard in forensic toxicology, opioid receptor pharmacology research, and novel psychoactive substance (NPS) monitoring programs.\u00a0<\/a>Biosynlab<\/strong><\/a>\u00a0delivers pharmaceutical-grade U-47700 with certified \u226599.0% purity, supporting cutting-edge research across\u00a0USA (DEA-licensed institutions), United Kingdom, European Union, and international forensic and scientific markets<\/strong>.<\/p>\n

The unique trans-cyclohexyl-dimethylamino substitution pattern combined with the 3,4-dichloro substitution on the benzamide ring creates a potent \u03bc-opioid receptor agonist with distinct structure-activity relationships compared to traditional morphinan opioids. This structural architecture<\/a> has made U-47700 invaluable for comparative studies with other synthetic opioids including fentanyl, AH-7921, MT-45, and novel fentanyl analogs. Forensic laboratories in\u00a0London, Berlin, Amsterdam, New York, and Los Angeles<\/strong>\u00a0rely on Biosynlab U-47700 for quantitative analysis in post-mortem toxicology, driving under the influence investigations, and monitoring of the evolving synthetic opioid landscape.<\/p>\n

Chemical Properties & Structural Characterization<\/strong><\/h3>\n

U-47700<\/strong>\u00a0belongs to the benzamide chemical class, specifically the N-cyclohexyl-N-methylbenzamide subclass characterized by a diarylamide structure with cyclohexyl substitution and dichloro substitution on the aromatic ring.<\/p>\n

Key Structural Features:<\/strong><\/p>\n

    \n
  • Core Scaffold:<\/strong>\u00a0N-methylbenzamide backbone<\/li>\n
  • Substitutions:<\/strong>\u00a03,4-dichloro on benzene ring, trans-2-(dimethylamino)cyclohexyl on amide nitrogen<\/li>\n
  • Stereochemistry:<\/strong>\u00a0Trans configuration of cyclohexyl substituents (critical for activity)<\/li>\n
  • Functional Groups:<\/strong>\u00a0Tertiary amide, tertiary amine (dimethylamino), dichloroaromatic<\/li>\n
  • Salt Form:<\/strong>\u00a0Hydrochloride (HCl) for enhanced stability and solubility<\/li>\n
  • Physical State:<\/strong>\u00a0Crystalline powder (highly potent, handle with extreme care)<\/li>\n<\/ul>\n

    Analytical Characteristics:<\/strong><\/p>\n

      \n
    • UV Absorption:<\/strong>\u00a0220 nm (strong), 280 nm (aromatic dichloro chromophore)<\/li>\n
    • Retention Time (HPLC):<\/strong>\u00a08.4-9.2 minutes (C18 column, gradient method)<\/li>\n
    • Mass Spec m\/z:<\/strong>\u00a0331.1\/333.1 [M+H]+ (chlorine isotope pattern, 3:1 ratio), 274.1 [M+H-dimethylamine]+, 246.1 [M+H-cyclohexyl]+<\/li>\n
    • NMR Signatures:<\/strong>\u00a0Cyclohexyl protons (1.2-2.8 ppm), N-methyl singlet (2.8-3.0 ppm), N,N-dimethyl singlet (2.2-2.4 ppm), aromatic protons (7.2-7.6 ppm, characteristic AB pattern)<\/li>\n<\/ul>\n

      Research Applications & Scientific Utility<\/strong><\/h3>\n

      Opioid Receptor Pharmacology:<\/strong>
      \nU-47700 serves as a critical tool compound for investigating \u03bc-opioid receptor (MOR) pharmacology. Research applications include:<\/p>\n

        \n
      • \u03bc-Opioid receptor binding affinity determination (Ki ~5-10 nM, selective MOR agonist)<\/li>\n
      • Structure-activity relationship studies in benzamide opioids<\/li>\n
      • Comparison with fentanyl, morphine, AH-7921, and MT-45<\/li>\n
      • Receptor selectivity profiling (MOR vs. DOR vs. KOR)<\/li>\n
      • G-protein coupling and \u03b2-arrestin recruitment studies<\/li>\n
      • Bias agonism and signaling pathway investigations<\/li>\n<\/ul>\n

        Forensic Toxicology & Opioid Crisis Research:<\/strong>
        \nCertified reference standard applications include:<\/p>\n

          \n
        • LC-MS\/MS method development for ultra-low level detection (pg\/mL)<\/li>\n
        • Post-mortem toxicology case work (overdose investigations)<\/li>\n
        • Differentiation of pharmaceutical vs. illicitly manufactured U-47700<\/li>\n
        • Novel fentanyl analog monitoring (acetylfentanyl, carfentanil, etc.)<\/li>\n
        • Driving under the influence (DUID) investigations<\/li>\n
        • Workplace drug testing assay validation (expanded panels)<\/li>\n<\/ul>\n

          Novel Psychoactive Substance (NPS) Research:<\/strong><\/p>\n

            \n
          • Structure-activity relationships in designer opioids<\/li>\n
          • Potency comparisons and structure-toxicity relationships<\/li>\n
          • Detection method development for emerging analogs<\/li>\n
          • International drug surveillance and early warning systems<\/li>\n
          • Metabolite identification and profiling<\/li>\n<\/ul>\n

            Clinical Pharmacology Research:<\/strong><\/p>\n

              \n
            • Opioid receptor pharmacology in pain management research<\/li>\n
            • Structure-potency relationships<\/li>\n
            • Addiction and dependence mechanism studies<\/li>\n
            • Respiratory depression liability assessment<\/li>\n
            • Comparison with prescription and illicit opioids<\/li>\n<\/ul>\n

              Analytical Chemistry:<\/strong><\/p>\n

                \n
              • GC-MS method development (challenges due to thermal lability)<\/li>\n
              • LC-MS\/MS validation for low-level detection<\/li>\n
              • Immunoassay cross-reactivity studies<\/li>\n
              • Isomeric separation (cis vs. trans isomers)<\/li>\n
              • Stability studies in various matrices<\/li>\n<\/ul>\n

                Synthesis & Quality Control Protocols<\/strong><\/h3>\n

                Biosynlab’s U-47700 production adheres to rigorous pharmaceutical-grade standards with extreme safety protocols:<\/p>\n

                Synthetic Route:<\/strong><\/p>\n

                  \n
                1. Starting Material:<\/strong>\u00a03,4-Dichlorobenzoic acid or appropriate precursor<\/li>\n
                2. Activation:<\/strong>\u00a0Formation of acid chloride or activated ester<\/li>\n
                3. Amide Formation:<\/strong>\u00a0Reaction with trans-2-(dimethylamino)cyclohexylamine<\/li>\n
                4. N-Methylation:<\/strong>\u00a0Methylation of amide nitrogen<\/li>\n
                5. Purification:<\/strong>\u00a0Multi-step recrystallization and chromatography<\/li>\n
                6. Salt Formation:<\/strong>\u00a0HCl salt preparation for optimal stability<\/li>\n
                7. Drying:<\/strong>\u00a0Vacuum desiccation under inert atmosphere<\/li>\n
                8. Isomeric Purity:<\/strong>\u00a0Verification of trans configuration<\/li>\n<\/ol>\n

                  Analytical Verification:<\/strong><\/p>\n

                    \n
                  • HPLC-PDA:<\/strong>\u00a0Purity \u226599.0%, impurity profiling (cis-isomer, AH-7921, desmethyl) <0.5%<\/li>\n
                  • \u00b9H NMR (400 MHz):<\/strong>\u00a0Complete structural assignment, stereochemistry confirmation<\/li>\n
                  • \u00b9\u00b3C NMR (100 MHz):<\/strong>\u00a0Carbon environment verification<\/li>\n
                  • 2D NMR (COSY, HSQC, HMBC):<\/strong>\u00a0Correlation spectroscopy for structure proof<\/li>\n
                  • LC-MS\/MS:<\/strong>\u00a0Molecular weight confirmation, fragmentation analysis<\/li>\n
                  • FTIR-ATR:<\/strong>\u00a0Amide carbonyl (1640-1680 cm\u207b\u00b9), C-Cl stretches (800-900 cm\u207b\u00b9)<\/li>\n
                  • DSC:<\/strong>\u00a0Melting point determination, thermal stability, polymorph screening<\/li>\n
                  • TGA:<\/strong>\u00a0Thermal gravimetric analysis<\/li>\n
                  • Chiral HPLC:<\/strong>\u00a0Verification of trans configuration, absence of cis-isomer<\/li>\n
                  • Residual Solvent:<\/strong>\u00a0GC-HS per ICH Q3C guidelines<\/li>\n
                  • Heavy Metals:<\/strong>\u00a0ICP-MS for Class 1 and 2 elements<\/li>\n
                  • Water Content:<\/strong>\u00a0Karl Fischer titration<\/li>\n<\/ul>\n

                    Extreme Safety Considerations:<\/strong><\/p>\n

                      \n
                    • Potency Warning:<\/strong>\u00a0Active at microgram doses; lethal at milligram doses<\/li>\n
                    • Dermal Absorption:<\/strong>\u00a0Transdermal penetration risk; avoid skin contact<\/li>\n
                    • Inhalation Risk:<\/strong>\u00a0Extremely hazardous if powder becomes airborne<\/li>\n
                    • Cross-Contamination:<\/strong>\u00a0Rigorous cleaning protocols required<\/li>\n<\/ul>\n

                      Batch Documentation:<\/strong><\/p>\n

                        \n
                      • Certificate of Analysis (COA) with complete analytical data<\/li>\n
                      • Material Safety Data Sheet (MSDS) with extreme hazard warnings<\/li>\n
                      • DEA Form 222 documentation (USA)<\/li>\n
                      • Stability testing data (accelerated and real-time)<\/li>\n
                      • Chain of custody documentation<\/li>\n<\/ul>\n

                        Packaging, Storage & Logistics<\/strong><\/h3>\n

                        Primary Containment (Triple Containment):<\/strong><\/p>\n

                          \n
                        • Inner: Sealed amber glass vial (5-20mL)<\/li>\n
                        • Middle: PTFE-lined secondary container with absorbent<\/li>\n
                        • Outer: Rigid impact-resistant container with tamper-evident seals<\/li>\n
                        • Argon headspace to prevent oxidation<\/li>\n
                        • Multiple indicating silica gel desiccant packets<\/li>\n
                        • Emergency spill cleanup materials included<\/li>\n<\/ul>\n

                          Secondary Packaging:<\/strong><\/p>\n

                            \n
                          • Rigid protective containers with custom foam inserts<\/li>\n
                          • Shock-absorbing packaging materials<\/li>\n
                          • Plain unmarked cardboard exterior<\/li>\n
                          • Temperature-controlled packaging with phase-change materials<\/li>\n<\/ul>\n

                            Storage Specifications:<\/strong><\/p>\n

                              \n
                            • Recommended:<\/strong>\u00a0-20\u00b0C freezer, desiccated, inert atmosphere<\/li>\n
                            • Short-term:<\/strong>\u00a02-8\u00b0C refrigerator (<3 months)<\/li>\n
                            • Ambient:<\/strong>\u00a0Not recommended<\/li>\n
                            • Stability:<\/strong>\u00a012+ months at -20\u00b0C with proper handling<\/li>\n
                            • Security:<\/strong>\u00a0Vault storage with dual-lock, access logging<\/li>\n<\/ul>\n

                              Handling Protocols:<\/strong><\/p>\n

                                \n
                              • DEA Schedule I facility required (USA)<\/strong><\/li>\n
                              • Vault storage with appropriate security<\/strong><\/li>\n
                              • Comprehensive inventory tracking (weighed, perpetual)<\/strong><\/li>\n
                              • Fume hood mandatory for all handling<\/strong><\/li>\n
                              • NIOSH-approved respirator (P100 or equivalent)<\/strong><\/li>\n
                              • Nitrile gloves (double-gloving), face shield, lab coat<\/strong><\/li>\n
                              • Emergency naloxone (Narcan\u00ae) immediately available<\/strong><\/li>\n
                              • Emergency eyewash and safety shower access<\/strong><\/li>\n
                              • Spill containment kits with opioid-specific absorbents<\/strong><\/li>\n
                              • Buddy system – NEVER handle alone<\/strong><\/li>\n
                              • Proper hazardous waste disposal per DEA regulations<\/strong><\/li>\n<\/ul>\n

                                Global Distribution & Regional Availability<\/strong><\/h3>\n

                                Biosynlab ships U-47700 only to appropriately licensed institutions:<\/p>\n

                                United States (DEA Schedule I – Licensed Institutions Only):<\/strong>
                                \nDEA-registered forensic laboratories, CDC opioid surveillance programs, government research agencies with Schedule I licenses<\/p>\n

                                United Kingdom (Home Office Licensed):<\/strong>
                                \nForensic laboratories, licensed research institutions, Home Office-approved facilities<\/p>\n

                                European Union (National Licenses):<\/strong>
                                \nGermany (BfArM), Netherlands (Opiumwet licensed), EMCDDA reference laboratories, licensed forensic facilities<\/p>\n

                                Other Regions:<\/strong>
                                \nCanada (Health Canada licensed), Australia (TGA licensed), international forensic organizations<\/p>\n

                                Shipping Specifications:<\/strong><\/p>\n

                                  \n
                                • Specialized controlled substance shipping (DEA Schedule I protocols USA)<\/li>\n
                                • Chain of custody documentation at every step<\/li>\n
                                • Signature confirmation and tracking mandatory<\/li>\n
                                • Dual-lock packaging for transit<\/li>\n
                                • Insurance coverage required<\/li>\n
                                • Customs documentation for international shipments<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

                                  Premium U-47700 Powder: Industrial Grade Supply for Advanced Research Applications   U-47700 (trans-3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide)\u00a0represents a synthetic opioid compound originally developed by Upjohn Pharmaceuticals in the 1970s as part of a series of kappa-opioid receptor selective agonists. As a structural analog of AH-7921 with distinct pharmacological properties, U-47700 has emerged as a critical reference standard in forensic […]<\/p>\n","protected":false},"featured_media":228,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[16],"product_tag":[14894,14895,14896,1327,1020,1021,1023,1024,1334,14897,1335,1028,1029,1336,14898,14899,1341,14900,14901,14902,14903,14904,14905,14906,14907,14908,14909,14910,14911,14912,1045,14913,14914,1349,14915,14916,1351,14917,1353,1355],"class_list":["post-223","product","type-product","status-publish","has-post-thumbnail","product_cat-buy-research-chemicals","product_tag-bulk-u-47700-powder","product_tag-buy-u-47700-wholesale","product_tag-industrial-u-47700-supplier","product_tag-u-47700-analytical-standard","product_tag-u-47700-asia","product_tag-u-47700-australia","product_tag-u-47700-bulk-order","product_tag-u-47700-canada","product_tag-u-47700-chemical-distributor","product_tag-u-47700-chemical-research","product_tag-u-47700-chemical-supplier","product_tag-u-47700-distributor","product_tag-u-47700-europe","product_tag-u-47700-for-research","product_tag-u-47700-handling-guidelines","product_tag-u-47700-laboratory-grade","product_tag-u-47700-manufacturer","product_tag-u-47700-powder-analysis","product_tag-u-47700-powder-bulk","product_tag-u-47700-powder-certificate","product_tag-u-47700-powder-documentation","product_tag-u-47700-powder-online","product_tag-u-47700-powder-order","product_tag-u-47700-powder-price","product_tag-u-47700-powder-purity","product_tag-u-47700-powder-sample","product_tag-u-47700-powder-shipping","product_tag-u-47700-powder-specifications","product_tag-u-47700-powder-usa","product_tag-u-47700-powder-wholesale-supplier","product_tag-u-47700-research-chemical","product_tag-u-47700-research-chemical-supplier","product_tag-u-47700-research-facility","product_tag-u-47700-research-grade","product_tag-u-47700-research-purposes","product_tag-u-47700-safety-data","product_tag-u-47700-synthesis","product_tag-u-47700-uk-supplier","product_tag-u-47700-vendor","product_tag-u-47700-wholesale-price","first","instock","sale","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"\nBuy 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