{"id":539,"date":"2026-06-07T23:41:37","date_gmt":"2026-06-07T23:41:37","guid":{"rendered":"https:\/\/biosynlab.com\/?post_type=product&p=539"},"modified":"2026-06-23T02:20:03","modified_gmt":"2026-06-23T02:20:03","slug":"mk-677-powder-istobal-nutrobal","status":"publish","type":"product","link":"https:\/\/www.biosynlab.com\/?product=mk-677-powder-istobal-nutrobal","title":{"rendered":"MK-677 Powder (Istobal\/Nutrobal)"},"content":{"rendered":"

Premium Industrial Grade MK-677 Powder (Ibutamoren\/Nutrobal) – Comprehensive Product Guide<\/h1>\n

 <\/p>\n

\n

Product Details Table<\/strong><\/h2>\n
\n
\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Attribute<\/strong><\/th>\nSpecification<\/strong><\/th>\n<\/tr>\n<\/thead>\n
Brand<\/strong><\/td>\nBioSynLab Research Compounds<\/td>\n<\/tr>\n
Product Name<\/strong><\/td>\nMK-677 (Ibutamoren Mesylate)<\/td>\n<\/tr>\n
Synonyms<\/strong><\/td>\nNutrobal, Istobal, Ibutamoren, MK-0677, L-163,191<\/td>\n<\/tr>\n
CAS Number<\/strong><\/td>\n159752-10-0 (freebase); 159634-47-4 (mesylate salt)<\/td>\n<\/tr>\n
Molecular Formula<\/strong><\/td>\nC\u2082\u2087H\u2083\u2086N\u2084O\u2085S \u00b7 CH\u2084O\u2083S (mesylate salt)<\/td>\n<\/tr>\n
Molecular Weight<\/strong><\/td>\n624.77 g\/mol (mesylate salt); 528.67 g\/mol (freebase)<\/td>\n<\/tr>\n
Salt Form<\/strong><\/td>\nMesylate (methanesulfonate)<\/td>\n<\/tr>\n
Purity<\/strong><\/td>\n\u226599.0% (HPLC Verified)<\/td>\n<\/tr>\n
Appearance<\/strong><\/td>\nWhite to Off-White Crystalline Powder<\/td>\n<\/tr>\n
Form<\/strong><\/td>\nMicronized Powder<\/td>\n<\/tr>\n
Particle Size<\/strong><\/td>\n20-50 microns<\/td>\n<\/tr>\n
Storage<\/strong><\/td>\n-20\u00b0C, Desiccated, Light Protected<\/td>\n<\/tr>\n
Packaging<\/strong><\/td>\nAmber Borosilicate Vials with PTFE Seals<\/td>\n<\/tr>\n
Available Quantities<\/strong><\/td>\n1g, 5g, 10g, 25g, 50g, 100g<\/td>\n<\/tr>\n
Documentation<\/strong><\/td>\nCOA, HPLC, NMR, MS, MSDS, Stability Data<\/td>\n<\/tr>\n
Shipping<\/strong><\/td>\nAmbient or Refrigerated, Discrete<\/td>\n<\/tr>\n
Origin<\/strong><\/td>\nEU\/GMP Certified Laboratory<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n
\n

<\/h2>\n
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<\/div>\n<\/div>\n<\/div>\n
\n

<\/h2>\n

MK-677 Powder (Ibutamoren Mesylate\/Nutrobal\/Istobal) | Growth Hormone Secretagogue Research Compound | BioSynLab<\/strong><\/h3>\n

BioSynLab<\/strong><\/a>\u00a0presents\u00a0pharmaceutical-grade MK-677 (Ibutamoren mesylate)<\/strong>\u00a0for\u00a0advanced endocrinological research<\/strong>\u00a0and\u00a0growth hormone secretagogue studies<\/strong>. Also known as\u00a0Nutrobal<\/strong>\u00a0or\u00a0Istobal<\/strong>, this\u00a0orally active non-peptide ghrelin receptor agonist<\/strong>\u00a0serves as a critical\u00a0research tool<\/strong>\u00a0for investigating\u00a0growth hormone (GH) release mechanisms<\/strong>,\u00a0insulin-like growth factor 1 (IGF-1) modulation<\/strong>, and\u00a0metabolic pathway research<\/strong>\u00a0in laboratory settings.<\/p>\n

Chemical Architecture & Mechanism of Action<\/strong><\/h3>\n

MK-677 (Ibutamoren)<\/strong>\u00a0is a\u00a0spiropiperidine derivative<\/strong>\u00a0that functions as a\u00a0potent, orally bioavailable growth hormone secretagogue<\/strong>:<\/p>\n

Structural Features:<\/strong><\/p>\n

    \n
  • Spiropiperidine Core:<\/strong>\u00a0Bicyclic structure providing\u00a0metabolic stability<\/strong>\u00a0and\u00a0oral bioavailability<\/strong><\/li>\n
  • Biphenylmethyl Substituent:<\/strong>\u00a0Enhances\u00a0lipophilicity<\/strong>\u00a0and\u00a0membrane permeability<\/strong><\/li>\n
  • Carboxamide Functionality:<\/strong>\u00a0Key pharmacophore for\u00a0ghrelin receptor (GHS-R1a) binding<\/strong><\/li>\n
  • Mesylate Salt Form:<\/strong>\u00a0Methanesulfonate counterion<\/strong>\u00a0ensuring\u00a0crystalline stability<\/strong>\u00a0and\u00a0enhanced solubility<\/strong><\/li>\n<\/ul>\n

    Mechanism of Action:<\/strong><\/p>\n

      \n
    • Ghrelin Receptor Agonist:<\/strong>\u00a0Mimics\u00a0endogenous ghrelin<\/strong>\u00a0(growth hormone-releasing peptide)<\/li>\n
    • GHS-R1a Activation:<\/strong>\u00a0Stimulates\u00a0pituitary growth hormone release<\/strong><\/li>\n
    • Somatostatin Inhibition:<\/strong>\u00a0Suppresses\u00a0somatostatin-mediated negative feedback<\/strong><\/li>\n
    • Oral Bioavailability:<\/strong>\u00a0Unlike\u00a0peptide GH secretagogues<\/strong>\u00a0(GHRP-6, Ipamorelin), MK-677 is\u00a0orally active<\/strong><\/li>\n<\/ul>\n

      Physicochemical Properties:<\/strong><\/p>\n

        \n
      • Molecular weight:<\/strong>\u00a0624.77 g\/mol (mesylate salt)<\/li>\n
      • Calculated LogP:<\/strong>\u00a03.2 (moderate lipophilicity)<\/li>\n
      • pKa (piperidine N):<\/strong>\u00a0~9.5 (protonated at physiological pH)<\/li>\n
      • Melting point:<\/strong>\u00a0156-162\u00b0C (mesylate salt)<\/li>\n
      • Chirality:<\/strong>\u00a0Single enantiomer (chiral center at spiro junction)<\/li>\n<\/ul>\n

        Analytical Characterization & Quality Verification<\/strong><\/h3>\n

        Each\u00a0BioSynLab MK-677<\/strong>\u00a0batch undergoes\u00a0comprehensive analytical profiling<\/strong>:<\/p>\n

        Chromatographic Analysis:<\/strong><\/p>\n

          \n
        • HPLC-UV (220nm):<\/strong>\u00a0\u226599.0% purity by area normalization<\/li>\n
        • Chiral HPLC:<\/strong>\u00a0Enantiomeric purity confirmation (>99% ee)<\/li>\n
        • Related substances:<\/strong>\u00a0<1.0% total impurities<\/li>\n
        • Residual solvents:<\/strong>\u00a0Meets ICH Q3C (methanol, ethanol, acetonitrile, dichloromethane)<\/li>\n<\/ul>\n

          Mass Spectrometry:<\/strong><\/p>\n

            \n
          • LC-MS\/MS:<\/strong>\u00a0[M+H]\u207a at m\/z 529.4 (freebase), fragmentation pattern matching reference<\/li>\n
          • High-Resolution MS:<\/strong>\u00a0Exact mass confirmation <5 ppm deviation<\/li>\n<\/ul>\n

            Nuclear Magnetic Resonance (NMR):<\/strong><\/p>\n

              \n
            • \u00b9H NMR (500MHz, DMSO-d\u2086):<\/strong>\n
                \n
              • Aromatic protons: \u03b4 7.15-7.45 (m, 9H)<\/li>\n
              • Spiropiperidine CH\u2082: \u03b4 2.8-3.4 (m, 8H)<\/li>\n
              • Amide NH: \u03b4 8.12 (br s, 1H)<\/li>\n
              • Mesylate CH\u2083: \u03b4 2.38 (s, 3H)<\/li>\n<\/ul>\n<\/li>\n
              • \u00b9\u00b3C NMR (125MHz):<\/strong>\u00a028 distinct carbon signals<\/li>\n
              • FTIR:<\/strong>\u00a0Amide C=O (1650 cm\u207b\u00b9), aromatic C-H (3050 cm\u207b\u00b9), S=O (1160 cm\u207b\u00b9)<\/li>\n<\/ul>\n

                Physical Testing:<\/strong><\/p>\n

                  \n
                • Water content:<\/strong>\u00a0<0.5% (Karl Fischer)<\/li>\n
                • Heavy metals:<\/strong>\u00a0<10 ppm (ICP-MS)<\/li>\n
                • Specific rotation:<\/strong>\u00a0[\u03b1]\u00b2\u2070D = -12\u00b0 to -16\u00b0 (c=1, methanol)<\/li>\n
                • Residue on ignition:<\/strong>\u00a0<0.1%<\/li>\n<\/ul>\n

                  Powder Engineering & Research Handling<\/strong><\/h3>\n

                  Our\u00a0micronized MK-677 mesylate powder<\/strong>\u00a0(20-50\u03bcm) optimizes\u00a0research applications<\/strong>:<\/p>\n

                  Solubility Profile:<\/strong><\/p>\n

                    \n
                  • Dimethyl sulfoxide (DMSO):<\/strong>\u00a0\u2265100 mg\/mL (excellent)<\/li>\n
                  • Methanol:<\/strong>\u00a0\u226580 mg\/mL (very good)<\/li>\n
                  • Ethanol:<\/strong>\u00a0\u226560 mg\/mL (good)<\/li>\n
                  • Water:<\/strong>\u00a0~10 mg\/mL (limited, requires warming)<\/li>\n
                  • Phosphate-buffered saline (PBS):<\/strong>\u00a0~5 mg\/mL (with sonication)<\/li>\n<\/ul>\n

                    Recommended Stock Solutions:<\/strong><\/p>\n

                      \n
                    • 10 mM DMSO stock:<\/strong>\u00a0Dissolve 6.25mg in 1mL anhydrous DMSO<\/li>\n
                    • Storage:<\/strong>\u00a0-20\u00b0C in\u00a0aliquoted portions<\/strong><\/li>\n
                    • Working solutions:<\/strong>\u00a0Prepare fresh daily in\u00a0aqueous buffers<\/strong><\/li>\n<\/ul>\n

                      Handling Precautions:<\/strong><\/p>\n

                        \n
                      • Light protection:<\/strong>\u00a0Amber glassware or foil wrapping (photosensitive)<\/li>\n
                      • Temperature control:<\/strong>\u00a0Maintain frozen until use<\/li>\n
                      • Desiccation:<\/strong>\u00a0Keep desiccated to prevent\u00a0hydrolysis of mesylate salt<\/strong><\/li>\n<\/ul>\n

                        Research Applications & Scientific Significance<\/strong><\/h3>\n

                        MK-677<\/strong>\u00a0serves critical functions in\u00a0multiple research disciplines<\/strong>:<\/p>\n

                        Endocrinology & Metabolism:<\/strong><\/p>\n

                          \n
                        • Growth hormone release<\/strong>\u00a0assays (pituitary cell cultures)<\/li>\n
                        • IGF-1 induction<\/strong>\u00a0studies (liver cell models)<\/li>\n
                        • Ghrelin receptor signaling<\/strong>\u00a0(GHS-R1a pathway mapping)<\/li>\n
                        • Somatostatin modulation<\/strong>\u00a0(hypothalamic feedback mechanisms)<\/li>\n<\/ul>\n

                          Musculoskeletal Research:<\/strong><\/p>\n

                            \n
                          • Bone density<\/strong>\u00a0and\u00a0mineralization<\/strong>\u00a0studies<\/li>\n
                          • Muscle protein synthesis<\/strong>\u00a0assays<\/li>\n
                          • Nitrogen retention<\/strong>\u00a0investigations<\/li>\n
                          • Tissue repair<\/strong>\u00a0and\u00a0regeneration<\/strong>\u00a0models<\/li>\n<\/ul>\n

                            Metabolic Studies:<\/strong><\/p>\n

                              \n
                            • Appetite stimulation<\/strong>\u00a0mechanisms (hypothalamic neuropeptide Y)<\/li>\n
                            • Glucose homeostasis<\/strong>\u00a0(insulin sensitivity research)<\/li>\n
                            • Lipid metabolism<\/strong>\u00a0(fat oxidation pathways)<\/li>\n
                            • Energy expenditure<\/strong>\u00a0quantification<\/li>\n<\/ul>\n

                              Aging & Longevity Research:<\/strong><\/p>\n

                                \n
                              • Growth hormone deficiency<\/strong>\u00a0models<\/li>\n
                              • Sarcopenia<\/strong>\u00a0(age-related muscle loss) studies<\/li>\n
                              • Osteoporosis<\/strong>\u00a0research<\/li>\n
                              • Cognitive aging<\/strong>\u00a0(neuroprotective effects)<\/li>\n<\/ul>\n

                                Pharmacokinetic Research:<\/strong><\/p>\n

                                  \n
                                • Oral bioavailability<\/strong>\u00a0comparisons (vs. injectable GH)<\/li>\n
                                • Plasma half-life<\/strong>\u00a0determination (~4-6 hours in humans)<\/li>\n
                                • Metabolic stability<\/strong>\u00a0(CYP450 profiling)<\/li>\n
                                • Tissue distribution<\/strong>\u00a0studies<\/li>\n<\/ul>\n

                                  Global Distribution & Discrete Procurement<\/strong><\/h3>\n

                                  BioSynLab provides\u00a0secure, compliant distribution<\/strong>:<\/p>\n

                                  Packaging Specifications:<\/strong><\/p>\n

                                    \n
                                  • Primary:<\/strong>\u00a0Amber Type I borosilicate glass<\/li>\n
                                  • Secondary:<\/strong>\u00a0Argon-flushed\u00a0aluminized barrier pouch<\/strong><\/li>\n
                                  • Tertiary:<\/strong>\u00a0Discrete unmarked shipping containers<\/strong><\/li>\n<\/ul>\n

                                    Shipping Options:<\/strong><\/p>\n

                                      \n
                                    • Standard:<\/strong>\u00a0Ambient temperature, 5-7 days<\/li>\n
                                    • Refrigerated:<\/strong>\u00a02-8\u00b0C for extended stability<\/li>\n
                                    • Express:<\/strong>\u00a0Tracked courier, 2-3 days<\/li>\n
                                    • Discrete:<\/strong>\u00a0No product identifiers, generic return addresses<\/li>\n<\/ul>\n

                                      Service Coverage:<\/strong><\/p>\n

                                      United Kingdom:<\/strong>\u00a0London, Manchester, Birmingham, Leeds, Glasgow, Liverpool, Sheffield, Bristol, Edinburgh, Cardiff, Belfast, Nottingham, Leicester.<\/p>\n

                                      European Union:<\/strong>\u00a0Berlin, Hamburg, Munich, Cologne, Frankfurt, Amsterdam, Rotterdam, Paris, Lyon, Barcelona, Madrid, Rome, Milan, Vienna, Brussels, Prague, Warsaw.<\/p>\n

                                      North America:<\/strong>\u00a0New York, Los Angeles, Chicago, Houston, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Toronto, Vancouver.<\/p>\n","protected":false},"excerpt":{"rendered":"

                                      Premium Industrial Grade MK-677 Powder (Ibutamoren\/Nutrobal) – Comprehensive Product Guide   Product Details Table Attribute Specification Brand BioSynLab Research Compounds Product Name MK-677 (Ibutamoren Mesylate) Synonyms Nutrobal, Istobal, Ibutamoren, MK-0677, L-163,191 CAS Number 159752-10-0 (freebase); 159634-47-4 (mesylate salt) Molecular Formula C\u2082\u2087H\u2083\u2086N\u2084O\u2085S \u00b7 CH\u2084O\u2083S (mesylate salt) Molecular Weight 624.77 g\/mol (mesylate salt); 528.67 g\/mol (freebase) Salt […]<\/p>\n","protected":false},"featured_media":569,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[2236,2275,2237],"product_tag":[16620,16621,16622,16623,16624,16625,16626,16627,16628,16629,16630,16631,16632,16633,16634,16635,16636,16637,16638,16639,16640,16641,16642,16643,16644,16645,16646,16647,16648,16649,16650,16651,16652,16653,16654,16655,16656,16657,16658],"class_list":["post-539","product","type-product","status-publish","has-post-thumbnail","product_cat-fat-loss-cutting","product_cat-muscle-growth-bulking","product_cat-sarms-next-lvl-muscle","product_tag-buy-mk-677-powder-ghent","product_tag-buy-mk-677-powder-limerick","product_tag-buy-mk-677-powder-madrid","product_tag-buy-mk-677-powder-online-toronto","product_tag-buy-mk-677-powder-salzburg","product_tag-mk-677-powder-abu-dhabi-delivery","product_tag-mk-677-powder-amsterdam-buy","product_tag-mk-677-powder-austin-supplier","product_tag-mk-677-powder-berlin-online","product_tag-mk-677-powder-bologna-online","product_tag-mk-677-powder-bruges-buy","product_tag-mk-677-powder-bruges-online","product_tag-mk-677-powder-calgary-shipping","product_tag-mk-677-powder-dubai-shipping","product_tag-mk-677-powder-geneva","product_tag-mk-677-powder-gothenburg","product_tag-mk-677-powder-halifax-supplier","product_tag-mk-677-powder-houston","product_tag-mk-677-powder-klagenfurt-buy","product_tag-mk-677-powder-krakow-supplier","product_tag-mk-677-powder-leuven-for-sale","product_tag-mk-677-powder-ljubljana","product_tag-mk-677-powder-luxembourg","product_tag-mk-677-powder-nagoya-for-sale","product_tag-mk-677-powder-netherlands-supplier","product_tag-mk-677-powder-osaka-store","product_tag-mk-677-powder-ottawa-store","product_tag-mk-677-powder-plovdiv","product_tag-mk-677-powder-porto","product_tag-mk-677-powder-prague","product_tag-mk-677-powder-san-diego-buy","product_tag-mk-677-powder-sofia-shipping","product_tag-mk-677-powder-tampa-store","product_tag-mk-677-powder-tokyo-shop","product_tag-mk-677-powder-toulouse-store","product_tag-mk-677-powder-valencia","product_tag-mk-677-powder-vancouver","product_tag-mk-677-powder-vienna-vendor","product_tag-mk-677-powder-zurich-vendor","first","instock","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"\nBuy MK-677 Powder \u2013 Enhance Growth Hormone & Recovery<\/title>\n<meta name=\"description\" content=\"Buy MK-677 Ibutamoren powder online at BioSynLab. \u226599% purity, lab-tested Nutrobal\/Istobal. 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