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3-CL-PCP Crystal

3-CL-PCP

3-Cl-PCP HCl (3-Chlorophencyclidine) (CAS 1934-43-6) — High-Purity Research Chemical

Product Summary

3-Chloro-PCP hydrochloride, formally known as 1-[1-(3-chlorophenyl)cyclohexyl]piperidine hydrochloride and identified by CAS Registry Number 1934-43-6 (HCl salt), is a high-purity arylcyclohexylamine-class research chemical available at BiosynLab.com for qualified laboratory and in-vitro research applications. 3-Cl-PCP (also designated 3′-Cl-PCP) is a structural analogue of phencyclidine (PCP) in which the phenyl ring bears a chlorine substituent at the meta (3-) position. It belongs to the arylcyclohexylamine family of dissociative NMDA receptor antagonists, a class of significant scientific interest due to its relevance to glutamatergic neurotransmission research and its structural relationship to PCP, ketamine, and related compounds. Published pharmacological data indicate that 3-Cl-PCP exhibits comparable potency to PCP, with somewhat greater potency as an NMDA receptor antagonist and similar potency as a dopamine reuptake inhibitor. Each batch is synthesized under controlled conditions and independently verified through third-party analytical testing to confirm identity, purity, and consistency. Our 3-Cl-PCP HCl is supplied with a complete Certificate of Analysis (COA) documenting purity percentage, analytical methods used, and quality control results, ensuring full traceability from synthesis to shipment.
BiosynLab.com is committed to supplying research-grade compounds that meet the rigorous demands of academic, pharmaceutical, and industrial research institutions. Whether your work involves NMDA receptor binding studies, arylcyclohexylamine structure-activity relationship (SAR) research, dopamine transporter pharmacology, or analytical method development, 3-Cl-PCP HCl from BiosynLab is produced to deliver reproducible, publication-quality results.

Chemical & Physical Properties

 

Property
Details
Chemical Name (IUPAC, free base)
1-[1-(3-chlorophenyl)cyclohexyl]piperidine
Common Name(s)
3-Cl-PCP; 3′-Cl-PCP; 3-chloro-PCP; 3-chlorophencyclidine
CAS Number (free base)
2201-32-3
CAS Number (HCl salt)
1934-43-6
PubChem CID (free base)
125502037
UNII (free base)
BG2WV34L9L
Molecular Formula (free base)
C17H24ClN
Molecular Formula (HCl salt)
C17H24ClN · HCl
Molecular Weight (free base)
277.8 g/mol
Molecular Weight (HCl salt)
314.3 g/mol
Appearance
White to off-white crystalline solid
Purity
≥ 98% (determined by HPLC)
Solubility
Soluble in DMSO, ethanol, and methanol; HCl salt soluble in aqueous media
LogP (XLogP3, free base)
4.3
Topological Polar Surface Area
3.2 Ų
Hydrogen Bond Donors (free base)
0
Hydrogen Bond Acceptors (free base)
1
Rotatable Bonds
2
SMILES (free base)
C1CCC(CC1)(C2=CC(=CC=C2)Cl)N3CCCCC3
InChIKey
HUHBTESMMFLCAN-UHFFFAOYSA-N
Storage Conditions
Store at −20°C, protected from light and moisture
Shelf Life
24 months from manufacture date when stored as directed

Synthesis & Quality Control

Every batch of 3-Cl-PCP HCl produced at BiosynLab is manufactured in compliance with stringent quality management protocols. Our synthesis pipeline follows documented standard operating procedures (SOPs), and each production run undergoes multi-stage quality verification before release.
Analytical testing typically includes:
  • High-Performance Liquid Chromatography (HPLC) for purity quantification
  • Nuclear Magnetic Resonance (NMR) spectroscopy (1H and 13C) for structural identity confirmation, with particular attention to the 3-chloro ring substitution pattern and verification of the piperidine and cyclohexyl ring systems
  • High-Resolution Mass Spectrometry (HRMS / LC-Q-TOF-MS) for molecular weight and formula verification
  • Gas Chromatography–Mass Spectrometry (GC-MS) for impurity profiling and structural confirmation, including detection of regioisomeric arylcyclohexylamine impurities (2-Cl-PCP, 4-Cl-PCP)
  • Liquid Chromatography–Photodiode Array–Mass Spectrometry (LC-PDA-MS) for chromatographic purity and UV spectral confirmation
  • Melting point determination for solid-form characterization
  • Residual solvent analysis in accordance with ICH Q3C guidelines
  • Heavy metal screening to confirm compliance with safety thresholds
  • Isomeric purity verification to confirm the 3-chloro positional isomer and exclude 2- and 4-chloro isomers
  • Residual amine and precursor screening to detect synthetic intermediates
A full Certificate of Analysis accompanies every order and is available for download from your BiosynLab.com account or upon request prior to purchase.

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