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3-CMC Crystal Chunks

3-CMC (Meow)

3-CMC HCl (3-Chloromethcathinone / Clophedrone) (CAS 1607439-32-6) — High-Purity Research Chemical

Product Summary

3-Chloromethcathinone hydrochloride, formally known as 1-(3-chlorophenyl)-2-(methylamino)propan-1-one hydrochloride and identified by CAS Registry Number 1607439-32-6 (HCl salt), is a high-purity synthetic cathinone-class research chemical available at BiosynLab.com for qualified laboratory and in-vitro research applications. Commonly referred to as 3-CMC, clophedrone, or colloquially by the street name “Meow,” this compound is a ring-substituted methcathinone derivative structurally related to mephedrone (4-MMC), 3-MMC, 4-CMC, and bupropion. 3-CMC belongs to the synthetic cathinone family of new psychoactive substances (NPS), a class of significant scientific interest due to its interactions with monoamine neurotransmitter transporters (DAT, NET, SERT) and its relevance to psychostimulant pharmacology research. Published pharmacological data characterize 3-CMC as a monoamine releasing agent with potent substrate activity at the dopamine transporter (DAT, EC50 = 26 nM) and norepinephrine transporter (NET, EC50 = 19 nM), and comparatively lower activity at the serotonin transporter (SERT, EC50 = 211 nM). Each batch is synthesized under controlled conditions and independently verified through third-party analytical testing to confirm identity, purity, and consistency. Our 3-CMC HCl is supplied with a complete Certificate of Analysis (COA) documenting purity percentage, analytical methods used, and quality control results, ensuring full traceability from synthesis to shipment.
BiosynLab.com is committed to supplying research-grade compounds that meet the rigorous demands of academic, pharmaceutical, and industrial research institutions. Whether your work involves monoamine transporter pharmacology, synthetic cathinone structure-activity relationship (SAR) research, analytical method development, or forensic toxicology, 3-CMC HCl from BiosynLab is produced to deliver reproducible, publication-quality results.

Chemical & Physical Properties

Property
Details
Chemical Name (IUPAC, free base)
1-(3-chlorophenyl)-2-(methylamino)propan-1-one
Common Name(s)
3-CMC; 3-Chloromethcathinone; Clophedrone; Metaclephedrone; 3-Cl-Methcathinone; PAL-434; “Meow” (colloquial)
CAS Number (free base)
1049677-59-9
CAS Number (HCl salt)
1607439-32-6
PubChem CID (free base)
50999285
PubChem CID (HCl salt)
90645589
UNII (free base)
I2GB1C4TM7
ChemSpider ID
24958143
ChEMBL ID
3305871
Molecular Formula (free base)
C10H12ClNO
Molecular Formula (HCl salt)
C10H12ClNO · HCl (C10H13Cl2NO)
Molecular Weight (free base)
197.66 g/mol
Molecular Weight (HCl salt)
234.12 g/mol
Appearance
White to off-white crystalline solid
Purity
≥ 98% (determined by HPLC)
Solubility
Soluble in DMSO, methanol, ethanol, and aqueous media (HCl salt)
LogP (XLogP3, free base)
2.2
Topological Polar Surface Area
29.1 Ų
Hydrogen Bond Donors (free base)
1
Hydrogen Bond Acceptors (free base)
2
Rotatable Bonds
3
SMILES (free base)
CC(C(=O)C1=CC(=CC=C1)Cl)NC
InChIKey (free base)
VOEFELLSAAJCHJ-UHFFFAOYSA-N
InChIKey (HCl salt)
QXEPSICDXPPHTO-UHFFFAOYSA-N
Storage Conditions
Store at −20°C, protected from light and moisture
Shelf Life
24 months from manufacture date when stored as directed

Synthesis & Quality Control

Every batch of 3-CMC HCl produced at BiosynLab is manufactured in compliance with stringent quality management protocols. Our synthesis pipeline follows documented standard operating procedures (SOPs), and each production run undergoes multi-stage quality verification before release.
Analytical testing typically includes:
  • High-Performance Liquid Chromatography (HPLC) for purity quantification
  • Nuclear Magnetic Resonance (NMR) spectroscopy (1H and 13C) for structural identity confirmation, with particular attention to the 3-chloro ring substitution pattern and verification of the β-keto methylamino propanone scaffold
  • High-Resolution Mass Spectrometry (HRMS / LC-Q-TOF-MS) for molecular weight and formula verification
  • Gas Chromatography–Mass Spectrometry (GC-MS) for impurity profiling and structural confirmation, including detection of positional isomers (2-CMC, 4-CMC) and synthetic precursors (3-chloropropiophenone)
  • Liquid Chromatography–Photodiode Array–Mass Spectrometry (LC-PDA-MS) for chromatographic purity and UV spectral confirmation
  • Melting point determination for solid-form characterization
  • Residual solvent analysis in accordance with ICH Q3C guidelines, including screening for brominated intermediates from alpha-halogenation synthesis
  • Heavy metal screening to confirm compliance with safety thresholds
  • Isomeric purity verification to confirm the 3-chloro positional isomer and exclude 2-CMC and 4-CMC regioisomers
  • Chiral composition assessment to document racemic (R/S) enantiomeric ratio, as 3-CMC contains one chiral center and is typically supplied as a racemic mixture
  • Residual amine and precursor screening to detect methylamine and 3-chloropropiophenone synthetic intermediates
A full Certificate of Analysis accompanies every order and is available for download from your BiosynLab.com account or upon request prior to purchase.

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