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3-FA Powder

3-FA

3-FA HCl (3-Fluoroamphetamine / PAL-353) (CAS 1716-59-2) — High-Purity Research Chemical

Product Summary

3-Fluoroamphetamine hydrochloride, formally known as 1-(3-fluorophenyl)propan-2-amine hydrochloride and identified by CAS Registry Number 1716-59-2 (HCl salt), is a high-purity substituted amphetamine-class research chemical available at BiosynLab.com for qualified laboratory and in-vitro research applications. Commonly referred to as 3-FA or by its research designation PAL-353, this compound is a ring-substituted amphetamine derivative structurally related to amphetamine, 4-fluoroamphetamine (4-FA), 2-fluoroamphetamine (2-FA), and methamphetamine. 3-FA belongs to the substituted amphetamine family of psychoactive compounds, a class of significant scientific interest due to its interactions with monoamine neurotransmitter transporters (DAT, NET, SERT) and its relevance to psychostimulant pharmacology and drug development research. Published pharmacological data characterize 3-FA as a potent monoamine releasing agent with similar potency to methamphetamine, exhibiting greater selectivity for dopamine and norepinephrine release over serotonin, with a rank order comparable to amphetamine itself. Each batch is synthesized under controlled conditions and independently verified through third-party analytical testing to confirm identity, purity, and consistency. Our 3-FA HCl is supplied with a complete Certificate of Analysis (COA) documenting purity percentage, analytical methods used, and quality control results, ensuring full traceability from synthesis to shipment.
BiosynLab.com is committed to supplying research-grade compounds that meet the rigorous demands of academic, pharmaceutical, and industrial research institutions. Whether your work involves monoamine transporter pharmacology, substituted amphetamine structure-activity relationship (SAR) research, transdermal drug delivery studies, or analytical method development, 3-FA HCl from BiosynLab is produced to deliver reproducible, publication-quality results.

Chemical & Physical Properties

Property
Details
Chemical Name (IUPAC, free base)
(RS)-1-(3-fluorophenyl)propan-2-amine
Common Name(s)
3-FA; 3-Fluoroamphetamine; PAL-353; 3-Fluroamphetamine
CAS Number (free base)
1626-71-7
CAS Number (HCl salt)
1716-59-2
PubChem CID (free base)
121501
PubChem CID (HCl salt)
54594211
UNII (free base)
4KKW6IBP5X
ChemSpider ID
108417
Molecular Formula (free base)
C9H12FN
Molecular Formula (HCl salt)
C9H12FN · HCl (C9H13ClFN)
Molecular Weight (free base)
153.20 g/mol
Molecular Weight (HCl salt)
189.66 g/mol
Appearance
White to off-white crystalline solid (HCl salt); free base is a liquid at room temperature
Purity
≥ 98% (determined by HPLC)
Solubility
Soluble in DMSO, methanol, ethanol, and aqueous media (HCl salt)
LogP (XLogP3, free base)
1.8
Topological Polar Surface Area
26.0 Ų
Hydrogen Bond Donors (free base)
1
Hydrogen Bond Acceptors (free base)
2
Rotatable Bonds
2
Boiling Point (free base)
208.2 °C
Density (free base)
~1.0 g/cm³
pKa
~10
SMILES (free base)
CC(CC1=CC(=CC=C1)F)N
InChIKey (free base)
PIOCLGPCMNPZFT-UHFFFAOYSA-N
InChIKey (HCl salt)
HKAIRPOFLITWEU-UHFFFAOYSA-N
Storage Conditions
Store at −20°C, protected from light and moisture
Shelf Life
24 months from manufacture date when stored as directed

Synthesis & Quality Control

Every batch of 3-FA HCl produced at BiosynLab is manufactured in compliance with stringent quality management protocols. Our synthesis pipeline follows documented standard operating procedures (SOPs), and each production run undergoes multi-stage quality verification before release.
Analytical testing typically includes:
  • High-Performance Liquid Chromatography (HPLC) for purity quantification
  • Nuclear Magnetic Resonance (NMR) spectroscopy (1H and 13C) for structural identity confirmation, with particular attention to the 3-fluoro ring substitution pattern and verification of the α-methyl phenethylamine scaffold
  • High-Resolution Mass Spectrometry (HRMS / LC-Q-TOF-MS) for molecular weight and formula verification
  • Gas Chromatography–Mass Spectrometry (GC-MS) for impurity profiling and structural confirmation, including detection of positional isomers (2-FA, 4-FA) and fluoromethamphetamine analogues (2-FMA, 3-FMA, 4-FMA)
  • Liquid Chromatography–Photodiode Array–Mass Spectrometry (LC-PDA-MS) for chromatographic purity and UV spectral confirmation
  • Melting point determination for solid-form characterization of the hydrochloride salt
  • Residual solvent analysis in accordance with ICH Q3C guidelines, including screening for synthetic precursors and reagents
  • Heavy metal screening to confirm compliance with safety thresholds
  • Isomeric purity verification to confirm the 3-fluoro positional isomer and exclude 2-fluoro and 4-fluoro regioisomers
  • Chiral composition assessment to document racemic (R/S) enantiomeric ratio, as 3-FA contains one chiral center and is typically supplied as a racemic mixture
  • Residual amine and precursor screening to detect synthetic intermediates
A full Certificate of Analysis accompanies every order and is available for download from your BiosynLab.com account or upon request prior to purchase.

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