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2/3-FEA Pellets 40mg/120mg

3-FEA

3-FEA HCl (3-Fluoroethamphetamine) (CAS 54982-43-3) — High-Purity Research Chemical

Product Summary

3-Fluoroethamphetamine hydrochloride, formally known as N-ethyl-1-(3-fluorophenyl)propan-2-amine hydrochloride and identified by CAS Registry Number 54982-43-3, is a high-purity substituted amphetamine-class research chemical available at BiosynLab.com for qualified laboratory and in-vitro research applications. Commonly referred to as 3-FEA, this compound is an N-ethyl analogue of 3-fluoroamphetamine (3-FA) and a ring-substituted derivative of ethamphetamine, structurally related to 3-FA, 4-FEA, ethylamphetamine, and fenfluramine. 3-FEA belongs to the substituted amphetamine family of psychoactive compounds, a class of significant scientific interest due to its interactions with monoamine neurotransmitter transporters (DAT, NET, SERT) and its relevance to psychostimulant pharmacology and structure-activity relationship research. Published pharmacological data characterize 3-FEA as a monoamine releasing agent that promotes the release of norepinephrine, dopamine, and serotonin. Compared to the unsubstituted ethamphetamine, 3-FEA is a weaker releaser of norepinephrine but a stronger releaser of both dopamine and serotonin, and it produced the strongest reinforcing effects in animal self-administration studies among a series of 3-substituted ethamphetamine derivatives tested. Each batch is synthesized under controlled conditions and independently verified through third-party analytical testing to confirm identity, purity, and consistency. Our 3-FEA HCl is supplied with a complete Certificate of Analysis (COA) documenting purity percentage, analytical methods used, and quality control results, ensuring full traceability from synthesis to shipment.
BiosynLab.com is committed to supplying research-grade compounds that meet the rigorous demands of academic, pharmaceutical, and industrial research institutions. Whether your work involves monoamine transporter pharmacology, substituted amphetamine structure-activity relationship (SAR) research, reinforcement and addiction behavioral pharmacology, or analytical method development, 3-FEA HCl from BiosynLab is produced to deliver reproducible, publication-quality results.

Chemical & Physical Properties

Property
Details
Chemical Name (IUPAC, free base)
N-ethyl-1-(3-fluorophenyl)propan-2-amine
Common Name(s)
3-FEA; 3-Fluoroethamphetamine; N-ethyl-3-fluoroamphetamine
CAS Number
54982-43-3
PubChem CID (free base)
57458869
PubChem CID (HCl salt)
137700471
UNII (free base)
7ZY9F4B6GT
ChemSpider ID
27050449
Molecular Formula (free base)
C11H16FN
Molecular Formula (HCl salt)
C11H16FN · HCl (C11H17ClFN)
Molecular Weight (free base)
181.25 g/mol
Molecular Weight (HCl salt)
217.71 g/mol
Appearance
White to off-white crystalline solid
Purity
≥ 98% (determined by HPLC)
Solubility
Soluble in DMSO, methanol, ethanol, and aqueous media (HCl salt)
LogP (XLogP3, free base)
2.7
Topological Polar Surface Area
12.0 Ų
Hydrogen Bond Donors (free base)
1
Hydrogen Bond Acceptors (free base)
2
Rotatable Bonds
4
SMILES (free base)
CCNC(C)CC1=CC(=CC=C1)F
InChIKey (free base)
CKPWHLGHHXSVJI-UHFFFAOYSA-N
InChIKey (HCl salt)
VWEIOFROPKRPJC-UHFFFAOYSA-N
Storage Conditions
Store at −20°C, protected from light and moisture
Shelf Life
24 months from manufacture date when stored as directed

Synthesis & Quality Control

Every batch of 3-FEA HCl produced at BiosynLab is manufactured in compliance with stringent quality management protocols. Our synthesis pipeline follows documented standard operating procedures (SOPs), and each production run undergoes multi-stage quality verification before release.
Analytical testing typically includes:
  • High-Performance Liquid Chromatography (HPLC) for purity quantification
  • Nuclear Magnetic Resonance (NMR) spectroscopy (1H and 13C) for structural identity confirmation, with particular attention to the 3-fluoro ring substitution pattern and verification of the N-ethyl α-methyl phenethylamine scaffold
  • High-Resolution Mass Spectrometry (HRMS / LC-Q-TOF-MS) for molecular weight and formula verification
  • Gas Chromatography–Mass Spectrometry (GC-MS) for impurity profiling and structural confirmation, including detection of positional isomers (2-FEA, 4-FEA), N-methyl analogues (3-FMA, 3-FA), and N-desethyl degradation products
  • Liquid Chromatography–Photodiode Array–Mass Spectrometry (LC-PDA-MS) for chromatographic purity and UV spectral confirmation
  • Melting point determination for solid-form characterization of the hydrochloride salt
  • Residual solvent analysis in accordance with ICH Q3C guidelines, including screening for synthetic precursors and reagents
  • Heavy metal screening to confirm compliance with safety thresholds
  • Isomeric purity verification to confirm the 3-fluoro positional isomer and exclude 2-fluoro and 4-fluoro regioisomers
  • Chiral composition assessment to document racemic (R/S) enantiomeric ratio, as 3-FEA contains one chiral center and is typically supplied as a racemic mixture
  • Residual amine and precursor screening to detect ethylamine and 3-fluorophenylacetone synthetic intermediates
A full Certificate of Analysis accompanies every order and is available for download from your BiosynLab.com account or upon request prior to purchase.

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