Description

Premium 5-MeO-DALT Powder: Industrial Grade Chemical for Advanced Research Applications

 

Product Details Table

 

 

5-MeO-DALT Powder | Premium Diallyltryptamine Research Compound | BioSynLab

 

BioSynLab delivers pharmaceutical-grade 5-MeO-DALT powder for advanced neuropharmacological research and comparative tryptamine studies. As the N,N-diallyl analog of 5-methoxytryptamine, this substituted indolealkylamine offers unique structure-activity relationship insights for investigators exploring serotonin receptor pharmacology, allyl group metabolic effects, and novel psychoactive substance (NPS) analytical characterization.

Chemical Architecture & Structural Distinctions

5-Methoxy-N,N-diallyltryptamine (5-MeO-DALT) represents a structurally unique tryptamine derivative incorporating three key modifications to the parent tryptamine scaffold:

5-Position Substitution: The methoxy group (-OCH₃) at the 5-position of the indole ring confers lipophilicity enhancement and modified electronic distribution compared to unsubstituted tryptamine, influencing 5-HT receptor binding affinity and blood-brain barrier penetration.

N,N-Diallyl Substitution: Unlike dimethyl (DMT), diethyl (DET), or dipropyl (DPT) substituents, the allyl groups (CH₂=CH-CH₂-) introduce unsaturated terminal olefins that may undergo metabolic epoxidation via cytochrome P450 enzymes, creating distinct pharmacokinetic profiles and metabolite spectra for biotransformation studies.

Freebase Configuration: Our powder formulation maintains the unprotonated freebase form, optimizing organic solvent solubility and stability compared to salt forms (hydrochloride, fumarate), with reduced hygroscopicity for extended shelf-life under proper storage.

Physicochemical Properties:

• Melting Point: 76-82°C (decomposition)
• pKa (indole NH): ~16.5 (DMSO)
• LogP (calculated): 4.2 (indicating significant lipophilicity)
• H-bond donors: 1 (indole N-H)
• H-bond acceptors: 2 (indole N, methoxy O)

Analytical Characterization & Batch Verification

Each BioSynLab 5-MeO-DALT production lot undergoes rigorous analytical profiling:

Chromatographic Analysis:

• Reverse-Phase HPLC (C18, 280nm detection): ≥98.5% purity by peak area
• Chiral HPLC: Confirms racemic mixture (no stereocenters present)
• TLC: Single spot (silica gel, multiple solvent systems)
• GC-MS: Thermal stability confirmation, molecular ion at m/z 270

Spectroscopic Confirmation:

• ¹H NMR (500MHz, CDCl₃):
  • Indole N-H: δ 8.12 (br s, 1H)
  • Aromatic H-4, H-6, H-7: δ 6.95-7.25 (m, 3H)
  • Methoxy: δ 3.82 (s, 3H, -OCH₃)
  • Allyl CH₂: δ 3.15 (d, 4H, J=6.2Hz, N-CH₂-)
  • Allyl CH=CH₂: δ 5.10-5.25 (m, 4H), 5.85-6.05 (m, 2H)
• ¹³C NMR (125MHz): 17 distinct carbon signals confirming structure
• FTIR: N-H stretch (3400 cm⁻¹), C=C allyl (1640 cm⁻¹), C-O-C ether (1080 cm⁻¹)
• UV-Vis: λmax 222nm, 275nm, 280nm (tryptophan-like chromophore)

Physical Testing:

• Residual solvents: Meets ICH Q3C (GC-HS headspace)
• Water content: <0.5% (Karl Fischer titration)
• Heavy metals: <10 ppm (ICP-MS, USP <232>)
• Sulfated ash: <0.1% (USP <281>)

Powder Engineering & Research Handling

Our micronized 5-MeO-DALT powder (40-80μm particle size) optimizes laboratory manipulation and solution preparation:

Solubility Profile:

• Chloroform: ≥100 mg/mL (excellent)
• Dichloromethane: ≥80 mg/mL (excellent)
• Methanol: ≥60 mg/mL (very good)
• Ethanol: ≥40 mg/mL (good)
• Acetonitrile: ≥50 mg/mL (good)
• Dimethyl sulfoxide (DMSO): ≥100 mg/mL (excellent)
• Aqueous buffers (pH 7.4): <1 mg/mL (poor, requires co-solvent)

Recommended Stock Solutions:

• 10 mM DMSO stock: Dissolve 2.70mg in 1mL DMSO (ultrapure, sterile)
• Working solutions: Dilute in aqueous buffer immediately before use
• Storage of solutions: -20°C, aliquoted to prevent freeze-thaw cycles

Handling Precautions:

• Anti-static precautions: Use grounded equipment and ionizing air blowers (powder may generate static)
• Light protection: Amber glassware or aluminum foil wrapping for solutions (photosensitive)
• Oxygen exclusion: Argon or nitrogen atmosphere for long-term solution storage

Research Applications & Scientific Utility

5-MeO-DALT serves multiple research disciplines:

Neuropharmacology:

• 5-HT1A/5-HT2A receptor binding affinity determination (radioligand competition)
• Structure-activity comparisons vs. 5-MeO-DMT, 5-MeO-DIPT, 5-MeO-MiPT
• Functional selectivity profiling (G-protein coupling vs. β-arrestin recruitment)
• Receptor occupancy studies using PET imaging ligands

Metabolic Biochemistry:

• CYP450 metabolism (allyl group epoxidation to reactive metabolites)
• Glutathione conjugation studies (detoxication pathway mapping)
• Phase I/Phase II biotransformation profiling
• Microsomal stability assays (t½ in liver S9 fractions)

Forensic Toxicology:

• NPS detection method development (LC-MS/MS, GC-MS libraries)
• Retention index databases for gas chromatography
• Isomeric differentiation from 4-MeO-DALT and 6-MeO-DALT
• Post-mortem toxicology reference standards

Analytical Chemistry:

• Mass spectrometry fragmentation pathway elucidation
• NMR spectral library contributions
• TLC Rf value databases for field testing
• Stability-indicating method development

Discrete Procurement & Global Distribution

BioSynLab maintains strategic distribution infrastructure ensuring rapid, compliant delivery:

Packaging Specifications:

• Primary: Amber Type I borosilicate glass (5-50mL capacity)
• Closure: PTFE-faced silicone septa with phenolic screw caps
• Secondary: Argon-flushed aluminized barrier pouches
• Tertiary: Discrete cardboard shipping boxes, unmarked
• Documentation: SDS, COA, HPLC, NMR in separate waterproof envelope

Shipping Options:

• Standard: Ambient with desiccant, 5-7 days (suitable for powder)
• Express: Tracked courier (DHL/FedEx/UPS), 2-3 days
• Cryogenic: -20°C with phase-change materials, for bulk orders
• Insurance: Full value coverage, customs brokerage support

Service Territories:

United Kingdom: London, Manchester, Birmingham, Leeds, Glasgow, Liverpool, Sheffield, Bristol, Edinburgh, Cardiff, Belfast, Nottingham, Leicester, Coventry, Brighton, Plymouth, Oxford, Cambridge.