Attribute	Specification
Brand	BioSynLab Research Compounds
Product Name	5-MeO-DMT Fumarate
IUPAC Name	3-[2-(Dimethylamino)ethyl]-5-methoxyindole fumarate
Synonyms	5-Methoxy-DMT, O-methylbufotenin, Toad extract analog
CAS Number	96096-55-8 (fumarate salt); 1019-45-0 (freebase)
Molecular Formula	C₁₄H₂₀N₂O · C₄H₄O₄
Molecular Weight	348.39 g/mol (salt); 218.29 g/mol (freebase equivalent)
Salt Form	Fumarate (1:1 stoichiometry)
Purity	≥99.0% (HPLC Verified)
Appearance	White to Off-White Crystalline Powder
Form	Micronized Crystalline Powder
Particle Size	20-60 microns
Storage	-20°C, Desiccated, Argon Atmosphere
Packaging	Amber Borosilicate Vials with PTFE Seals
Available Quantities	100mg, 250mg, 500mg, 1g, 5g
Documentation	COA, HPLC, NMR, MSDS, Stability Data, Residual Solvent Report
Shipping	Cryogenic, Temperature-Validated, Discrete
Origin	EU/GMP Certified Synthesis

5-MeO-DMT Fumarate Powder | Premium Serotonergic Research Compound | BioSynLab

BioSynLab presents pharmaceutical-grade 5-MeO-DMT fumarate for advanced neuropharmacological research and comparative tryptamine studies. As the N,N-dimethyl analog of 5-methoxytryptamine, this substituted indolealkylamine serves as a critical reference standard for investigating 5-HT1A/5-HT2A receptor pharmacology, default mode network disruption, and structure-activity relationships among short-acting psychedelics.

Chemical Architecture & Salt Form Advantages

5-Methoxy-N,N-dimethyltryptamine fumarate represents the hemifumarate salt of the freebase compound, offering enhanced stability and handling characteristics for laboratory research:

Structural Features:

• 5-Methoxy Substitution: Electron-donating group at 5-position enhances lipophilicity and modulates receptor binding compared to unsubstituted DMT
• N,N-Dimethyl Substitution: Tertiary amine confers metabolic resistance to monoamine oxidase (MAO) degradation, though 5-MeO-DMT remains a MAO substrate
• Fumarate Counterion: Dicarboxylic acid salt provides crystalline stability, reduced hygroscopicity, and improved shelf-life vs. hydrochloride or freebase forms

Physicochemical Properties:

• pKa (indole NH): ~16.8 (DMSO)
• pKa (dimethylamino): ~8.9 (aqueous)
• LogP (calculated): 3.4 (freebase equivalent)
• Melting Point: 178-182°C (decomposition, fumarate salt)
• Chirality: Achiral (no stereocenters)

Fumarate Salt Benefits:

• Enhanced oxidative stability compared to freebase
• Reduced volatility (lower inhalation risk during handling)
• Improved crystallinity for X-ray diffraction studies
• Compatible with aqueous formulations at physiological pH

Analytical Characterization & Quality Verification

Each BioSynLab 5-MeO-DMT fumarate batch undergoes comprehensive analytical profiling:

Chromatographic Analysis:

• HPLC-UV (280nm): ≥99.0% purity by area normalization
• Chiral HPLC: Confirms absence of chiral impurities (achiral compound)
• Ion Chromatography: Fumarate counterion stoichiometry confirmation (1:1 ratio)
• Residual solvents: Meets ICH Q3C (methanol, ethanol, acetonitrile, ethyl acetate)

Spectroscopic Confirmation:

• ¹H NMR (500MHz, DMSO-d₆):
  • Indole N-H: δ 10.85 (br s, 1H)
  • Aromatic H-4, H-6, H-7: δ 6.95-7.25 (m, 3H)
  • Methoxy: δ 3.78 (s, 3H, -OCH₃)
  • N-CH₂: δ 3.08 (t, 2H, J=7.2Hz)
  • CH₂-CH₂: δ 2.82 (t, 2H, J=7.2Hz)
  • N(CH₃)₂: δ 2.32 (s, 6H)
  • Fumarate H: δ 6.52 (s, 2H, olefinic)
• ¹³C NMR (125MHz): 19 distinct carbon signals
• FTIR: Fumarate C=O (1680, 1550 cm⁻¹), indole N-H (3400 cm⁻¹), C-O-C (1080 cm⁻¹)
• UV-Vis: λmax 218nm, 275nm, 280nm
• LC-MS/MS: [M+H]⁺ at m/z 219.1 (freebase), fragmentation pattern matching reference

Physical Testing:

• Water content: <0.5% (Karl Fischer)
• Heavy metals: <10 ppm (ICP-MS)
• Sulfated ash: <0.1%
• Specific rotation: N/A (achiral)
• X-ray powder diffraction (XRPD): Crystalline form confirmation

Powder Engineering & Research Handling

Our micronized 5-MeO-DMT fumarate powder (20-60μm) optimizes laboratory manipulation:

Solubility Profile:

• Dimethyl sulfoxide (DMSO): ≥100 mg/mL (preferred stock solvent)
• Methanol: ≥80 mg/mL
• Water (pH 5-6): ≥50 mg/mL (fumarate salt advantage)
• Ethanol: ≥60 mg/mL
• Phosphate-buffered saline (PBS): ≥30 mg/mL
• Acetonitrile: ≥40 mg/mL

Stock Solution Preparation:

• 10 mM aqueous stock: Dissolve 3.48mg in 1mL sterile water (pH adjusted to 5.5-6.5)
• Storage: -80°C in aliquoted portions to prevent freeze-thaw degradation
• Working solutions: Prepare fresh daily in physiological buffers

Handling Precautions:

• Anti-static measures: Grounded equipment, ionizing blowers (powder generates static)
• Light protection: Amber glassware or foil wrapping (photosensitive)
• Oxygen exclusion: Argon atmosphere for long-term storage
• Desiccation: Maintain <10% RH to prevent fumaric acid degradation

Research Applications & Scientific Significance

5-MeO-DMT fumarate serves critical functions in multiple research domains:

Neuropharmacology:

• 5-HT1A receptor affinity determination (nanomolar Kd values)
• 5-HT2A functional selectivity (Gαq vs. β-arrestin pathways)
• Default mode network (DMN) disruption quantification
• Receptor internalization kinetics (trafficking studies)
• Comparison with DMT (5-methoxy effect on duration/potency)

Psychopharmacology:

• Subjective effects modeling (mystical experience correlates)
• Tolerance and cross-tolerance investigations
• Set and setting experimental controls
• Therapeutic potential research (treatment-resistant depression models)

Forensic Toxicology:

• LC-MS/MS method development for biological matrices
• Retention time libraries for forensic screening
• Metabolite identification (6-hydroxy-5-MeO-DMT, bufotenin)
• Toad venom vs. synthetic differentiation (isotopic analysis)

Receptor Biochemistry:

• Radioligand binding assays ([³H]-5-HT, [¹²⁵I]-DOI competition)
• G-protein activation (GTPγS binding)
• Second messenger quantification (IP₁, calcium flux)
• Receptor crystallography (structural biology)

Comparative Studies:

• Structure-activity vs. 5-MeO-DiPT, 5-MeO-MiPT, 5-MeO-DALT
• Route of administration pharmacokinetic comparisons
• Species differences (rodent vs. human receptor homology)

Global Distribution & Licensed Research Supply

BioSynLab operates strict verification protocols for 5-MeO-DMT distribution given its Schedule I status in most jurisdictions:

Eligibility Requirements:

• DEA Schedule I research registration (USA)
• Home Office controlled drug license (UK)
• Health Canada exemption (Canada)
• Competent authority authorization (EU member states)

Packaging & Shipping:

• Cryogenic packaging: Dry ice (-78°C) with data loggers
• Discrete outer packaging: Unmarked, generic return addresses
• Documentation: Import/export permits, customs declarations prepared
• Insurance: Full value coverage with licensed courier services
• Chain of custody: Tamper-evident seals, signature required