Description
Industrial Grade Carfentanil (CAS 59708-52-0) – Comprehensive Product Guide
Chemical & Pharmacological Profile
| Property | Data |
|---|---|
| IUPAC Name | Methyl 1-(2-phenylethyl)-4-[phenyl(propanoyl)amino]piperidine-4-carboxylate |
| Molecular Formula | C₂₄H₃₀N₂O₃ |
| Molecular Weight | 394.5 g/mol |
| Drug Class | Synthetic opioid; 4-anilidopiperidine derivative |
| Mechanism | μ-opioid receptor (MOR) agonist |
| Potency | ~10,000× morphine; ~100× fentanyl |
Legitimate Use
Veterinary Medicine: Carfentanil is FDA-approved strictly as a tranquilizing agent for large wildlife only (elephants, elk, moose, bears). It is formulated as Wildnil® (veterinary label) and administered via projectile dart delivery systems by licensed veterinarians and wildlife professionals. It has no approved human medical use.
Thank you for reading this post, don't forget to subscribe!Pharmacodynamics
- Onset: Rapid (minutes)
- Duration: Extended (60–120 minutes in large mammals)
- Receptor Affinity: Extremely high binding affinity at μ-opioid receptors (Ki ≈ 0.024 nM)
- Therapeutic Index: Extremely narrow; lethal dose approximates effective dose
Regulatory Status
| Jurisdiction | Classification |
|---|---|
| United States | Schedule II Controlled Substance (DEA) |
| United Kingdom | Class A drug (Misuse of Drugs Act 1971) |
| European Union | Subject to control under Council Decision 2005/387/JHA |
| UN Convention | Schedule I (Single Convention on Narcotic Drugs) |
Safety & Toxicity
Carfentanil poses severe public health risks due to its extreme potency and ability to be absorbed through skin, inhaled, or ingested. Doses as small as 2 milligrams can be lethal to humans. It has been associated with overdose clusters when analogues contaminate heroin or counterfeit pharmaceutical supplies.
Antidote: Naloxone (Narcan) is the reversal agent, though multiple doses (4–10 mg+) may be required due to carfentanil’s high receptor affinity and prolonged binding.
Chemical Synthesis
Produced via standard 4-anilidopiperidine synthetic routes; precursor chemicals (N-phenethyl-4-piperidone, aniline derivatives) are internationally monitored under precursor control regulations.
