Description
U-47700 (trans-3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide)
PRODUCT DETAILS TABLE
| Specification | Details |
|---|---|
| Brand | Biosynlab |
| Product Name | U-47700 (trans-3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide) |
| IUPAC Name | trans-3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide |
| CAS Number | 121348-98-9 |
| Molecular Formula | C₁₆H₂₂Cl₂N₂O |
| Molecular Weight | 329.27 g/mol |
| Chemical Class | Synthetic opioid / Benzamide derivative |
| Purity | ≥99.0% (HPLC Verified) |
| Appearance | White to off-white crystalline powder |
| Melting Point | 142-146°C (hydrochloride salt) |
| Solubility | Soluble in DMSO, ethanol, methanol; moderately soluble in water (HCl salt) |
| Storage | -20°C, desiccated, away from light |
| Packaging | Amber glass vial with PTFE seal |
| Quantities | 100mg, 250mg, 500mg, 1g, bulk (licensed institutions) |
| Analysis | COA, NMR, MS, FTIR included |
| Shipping | Express courier, tracked, discreet, signature required |
| Regions | USA (DEA licensed), UK, Germany, Netherlands, EU, Canada |
U-47700 (trans-3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide) represents a synthetic opioid compound originally developed by Upjohn Pharmaceuticals in the 1970s as part of a series of kappa-opioid receptor selective agonists. As a structural analog of AH-7921 with distinct pharmacological properties, U-47700 has emerged as a critical reference standard in forensic toxicology, opioid receptor pharmacology research, and novel psychoactive substance (NPS) monitoring programs. Biosynlab delivers analytical-grade U-47700 with certified ≥99.0% purity, supporting cutting-edge research across USA (DEA-licensed institutions), United Kingdom, European Union, and international forensic and scientific markets.
The unique trans-cyclohexyl-dimethylamino substitution pattern combined with the 3,4-dichloro substitution on the benzamide ring creates a potent μ-opioid receptor agonist with distinct structure-activity relationships compared to traditional morphinan opioids. This structural architecture has made U-47700 invaluable for comparative studies with other synthetic opioids including fentanyl, AH-7921, MT-45, and novel fentanyl analogs. Forensic laboratories in London, Berlin, Amsterdam, New York, and Los Angeles rely on Biosynlab U-47700 for quantitative analysis in post-mortem toxicology, driving under the influence investigations, and monitoring of the evolving synthetic opioid landscape.
Chemical Properties & Structural Characterization
U-47700 belongs to the benzamide chemical class, specifically the N-cyclohexyl-N-methylbenzamide subclass characterized by a diarylamide structure with cyclohexyl substitution and dichloro substitution on the aromatic ring.
Key Structural Features:
- Core Scaffold: N-methylbenzamide backbone
- Substitutions: 3,4-dichloro on benzene ring, trans-2-(dimethylamino)cyclohexyl on amide nitrogen
- Stereochemistry: Trans configuration of cyclohexyl substituents (critical for activity)
- Functional Groups: Tertiary amide, tertiary amine (dimethylamino), dichloroaromatic
- Salt Form: Hydrochloride (HCl) for enhanced stability and solubility
- Physical State: Crystalline solid with characteristic melting profile
Analytical Characteristics:
- UV Absorption: 220 nm (strong), 280 nm (aromatic dichloro chromophore)
- Retention Time (HPLC): 8.4-9.2 minutes (C18 column, gradient method)
- Mass Spec m/z: 331.1/333.1 [M+H]+ (chlorine isotope pattern, 3:1 ratio), 274.1 [M+H-dimethylamine]+, 246.1 [M+H-cyclohexyl]+
- NMR Signatures: Cyclohexyl protons (1.2-2.8 ppm), N-methyl singlet (2.8-3.0 ppm), N,N-dimethyl singlet (2.2-2.4 ppm), aromatic protons (7.2-7.6 ppm, characteristic AB pattern)
