BIOSYNLAB Noopept Powder – Research Grade N-Phenylacetyl-L-Prolylglycine Ethyl Ester

 

Product Details Table

 

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Advanced Nootropic Research: The Gold Standard in Cognitive Compound Synthesis

Seeking a high-affinity AMPA receptor modulator for your neuropharmacological research? BIOSYNLAB delivers pharmaceutical-grade Noopept powder—synthesized to exacting specifications for laboratories, academic institutions, and industrial R&D facilities across the USA, Europe, and United Kingdom markets.

Noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111) represents the pinnacle of synthetic peptide-derived nootropic engineering. Originally developed at the Russian Academy of Medical Sciences, this proline-containing dipeptide has emerged as a critical reference compound for investigating glutamatergic neurotransmission, neuroplasticity mechanisms, and neuroprotective pathways.

Our synthesis protocol employs advanced solid-phase peptide synthesis (SPPS) methodologies combined with rigorous post-synthesis purification, delivering batch-to-batch consistency that meets the demanding standards of analytical chemistry and preclinical research.

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Chemical Structure & Mechanism of Action

Structural Classification: Noopept is a synthetic dipeptide analog derived from the endogenous neuropeptide cycloprolylglycine. Its molecular architecture features:

• Phenylacetyl moiety: Enhances blood-brain barrier permeability
• L-proline residue: Confers metabolic stability against peptidase degradation
• Glycine ethyl ester: Optimizes bioavailability and receptor binding affinity

Pharmacological Profile:

• Primary target: AMPA receptor complex modulation
• Secondary mechanisms: Enhanced BDNF expression, antioxidant enzyme upregulation
• Neuroprotective properties: Mitigation of glutamate excitotoxicity, amyloid-beta aggregation inhibition

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Industrial Applications & Research Implementations

Neuropharmacological Research

Noopept serves as a critical tool compound for:

• Glutamatergic system studies – AMPA receptor trafficking and synaptic plasticity investigation
• Neurodegenerative disease modeling – Parkinson’s, Alzheimer’s, and ischemic stroke research
• Cognitive enhancement protocols – Memory consolidation and learning mechanism studies
• Anxiolytic compound screening – GABAergic and serotonergic interaction analysis

Pharmaceutical Development

• Lead compound optimization for nootropic drug candidates
• Structure-activity relationship (SAR) studies
• Formulation development for CNS-targeted delivery systems

Analytical Chemistry

• High-performance liquid chromatography (HPLC) reference standard
• Mass spectrometry calibration material
• Nuclear magnetic resonance (NMR) spectroscopy standard

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Synthesis Methodology & Quality Assurance

Manufacturing Protocol:

1. Solid-Phase Peptide Synthesis (SPPS): Fmoc-based chemistry on Wang resin
2. Coupling Reagents: HBTU/HOBt activation for efficient amide bond formation
3. Deprotection: Piperidine-mediated Fmoc removal
4. Cleavage: TFA cocktail liberation from solid support
5. Purification: Preparative HPLC (C18 reverse-phase column)
6. Lyophilization: Vacuum freeze-drying for powder consistency
7. Micronization: Jet milling for optimal particle size distribution

Analytical Verification:

• HPLC Purity: ≥99.5% (UV detection at 220nm)
• Mass Spectrometry: Molecular ion confirmation (m/z 319.2 [M+H]+)
• NMR Spectroscopy: ¹H-NMR and ¹³C-NMR structural validation
• Chiral Purity: e.e. >99% (chiral HPLC analysis)
• Residual Solvent: GC-MS verification (ICH Q3C compliance)
• Heavy Metals: ICP-MS screening (Pb, Cd, Hg, As)

 

 

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Responsible Consumption & Research Disclaimer

⚠️ BIOSYNLAB Responsible Use Policy:

This product is sold strictly for research, laboratory analysis, and industrial applications only. Not intended for human consumption, dietary supplementation, or therapeutic use without appropriate regulatory approval and clinical trial authorization.

• For in vitro and in vivo research purposes only
• Handle exclusively within certified laboratory environments
• Utilize appropriate engineering controls (fume hoods, HEPA filtration)
• Personal protective equipment required: nitrile gloves, safety goggles, lab coat
• Review Material Safety Data Sheet (MSDS) prior to handling
• Comply with DEA, FDA, and local regulations regarding synthetic peptides

Regulatory Notice: Noopept is not approved for human consumption in the USA, EU, or UK. It is classified as a research chemical. Purchasers assume full responsibility for compliance with applicable controlled substance analog laws, research chemical regulations, and institutional biosafety protocols. BIOSYNLAB provides this compound exclusively to qualified research entities with appropriate documentation.

Storage & Stability: Product maintains chemical integrity for 24 months when stored at -20°C under inert atmosphere. Avoid repeated freeze-thaw cycles. Discard if discoloration or precipitation occurs.

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Why Research Facilities Choose BIOSYNLAB

1. Synthetic Excellence: Custom peptide synthesis capabilities with >99% purity guarantees
2. Documentation Package: Comprehensive COA, MSDS, NMR spectra, and synthesis report
3. Chain of Custody: Full traceability from raw materials to final product
4. Regulatory Compliance: REACH-registered, customs-bonded warehousing
5. Technical Support: PhD-level consultation on compound handling and experimental design
6. Secure Logistics: Temperature-monitored, insurance-covered international shipping

Ready to advance your neuropharmacological research with premium-grade Noopept? Contact BIOSYNLAB for bulk pricing, custom synthesis inquiries, or technical specifications. Our analytical team provides complimentary consultation on integration methodologies for receptor binding assays, electrophysiology studies, and behavioral pharmacology protocols.