Description
4-AcO-MET Pellets – 20mg
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Product Details Table
| Attribute | Specification |
|---|---|
| Brand | BioSynLab Research Compounds |
| Product Name | 4-AcO-MET Pellets (Metacetin) |
| IUPAC Name | 3-[2-[Ethyl(methyl)amino]ethyl]-1H-indol-4-yl acetate |
| Synonyms | Metacetin, 4-Acetoxy-MET, 4-Acetoxy-N-methyl-N-ethyltryptamine |
| CAS Number | 1445586-01-7 |
| Molecular Formula | C₁₅H₂₀N₂O₂ |
| Molecular Weight | 260.33 g/mol |
| Dosage Form | Pellets (Compressed Tablets) |
| Unit Dose | 20mg ± 0.5mg |
| Pellet Dimensions | 4mm diameter × 2mm height |
| Pellet Weight | 50mg total (20mg API + 30mg excipients) |
| Purity | ≥99.0% (HPLC Verified) |
| Appearance | White to Off-White Round Pellets |
| Imprint | BioSynLab logo (BSL) on one face |
| Packaging | Blister packs (10 pellets per sheet) |
| Storage | 2-8°C, Desiccated, Light Protected |
| Excipients | Microcrystalline cellulose, Magnesium stearate |
| Documentation | COA, HPLC, Dissolution Profile, MSDS |
| Shipping | Temperature-Controlled, Discrete |
| Origin | EU/GMP Certified Manufacturing |
Formulation Composition:
- Active Pharmaceutical Ingredient (API): 4-AcO-MET freebase – 20.0mg (40% w/w)
- Diluent: Microcrystalline cellulose (Avicel PH-102) – 28.5mg (57% w/w)
- Lubricant: Magnesium stearate (vegetable grade) – 1.5mg (3% w/w)
Physical Specifications:
- Hardness: 4-6 kp (kiloponds) – optimal for handling without friability
- Friability: <0.5% (USP <1216>) – minimal dust generation during transport
- Disintegration Time: 15-30 minutes in simulated gastric fluid (pH 1.2)
- Dissolution Profile: >80% API release within 45 minutes (USP <711> Apparatus 2)
The 4mm × 2mm cylindrical pellet geometry facilitates accurate dispensing using laboratory tweezers or automated counting systems, eliminating the weighing variability inherent in powder aliquoting. Embossed BSL marking ensures product authentication and prevents cross-contamination with other research materials.
Blister Packaging & Stability Preservation
4-AcO-MET pellets are packaged in pharmaceutical-grade cold-form aluminum (CFF) blisters providing superior barrier protection against moisture ingress, oxygen exposure, and photodegradation:
Primary Barrier Properties:
- Aluminum foil thickness: 25μm (OPA/Alu/PVC trilaminate)
- Water vapor transmission rate (WVTR): <0.01 g/m²/day at 40°C/75% RH
- Oxygen transmission rate (OTR): <0.1 cc/m²/day
- Light transmission: <0.01% (UV-Vis, 290-450nm)
Secondary Packaging:
- Child-resistant cartons with tamper-evident seals
- Silica gel desiccant canisters (non-contact, separate compartment)
- Batch-specific labeling with QR-coded COA access
- Temperature indicators (irreversible color-change strips)
Shelf Life: 36 months from manufacture date when stored at 2-8°C in original packaging. Accelerated stability testing (ICH Q1A) confirms <2% degradation after 6 months at 40°C/75% RH.
Analytical Verification & Quality Control
Each BioSynLab 4-AcO-MET pellet batch undergoes comprehensive release testing:
Identity & Purity:
- HPLC-UV (254nm): ≥99.0% purity by area normalization
- Retention time matching: vs. certified reference standard
- Related substances: <0.5% total impurities, <0.1% single impurity
- Residual solvents: Meets ICH Q3C limits (GC-HS)
Pellet-Specific Testing:
- Content uniformity: 10 pellets tested (USP <905>), RSD <6%
- Weight variation: 20 pellets weighed, meets USP <905> criteria
- Dissolution testing: n=6 pellets, Apparatus 2 (paddle), 50 RPM, 900mL pH 1.2 buffer
- Disintegration: USP <701>, simulated gastric fluid at 37°C
Spectroscopic Confirmation:
- ¹H NMR (400MHz): Acetyl proton singlet at δ 2.12 ppm confirms ester functionality
- FTIR: Ester carbonyl stretch at 1742 cm⁻¹, indole N-H at 3405 cm⁻¹
- LC-MS/MS: Molecular ion [M+H]⁺ at m/z 261.2, fragmentation pattern matching reference
Research Applications & Experimental Advantages
20mg 4-AcO-MET pellets provide standardized dosing for multiple research methodologies:
Pharmacokinetic Studies:
- Bioavailability comparisons (pellet vs. solution formulations)
- Food effect studies (fasted vs. fed state dissolution)
- Dose proportionality assessments (linear pharmacokinetics validation)
- Steady-state accumulation modeling
In-Vitro Dissolution Research:
- Biorelevant media testing (FaSSIF, FeSSIF, simulated intestinal fluid)
- pH-dependent release profiling (pH 1.2, 4.5, 6.8)
- Sink condition validation for dissolution method development
- Formulation comparison studies (pellet vs. capsule vs. tablet)
Forensic & Toxicological Analysis:
- Tablet identification databases (physical characteristics library)
- Dissolution extraction methods for bioanalytical sample preparation
- Stability-indicating assays for evidence storage studies
- Counterfeit detection protocols (authenticity verification)
Behavioral Pharmacology:
- Standardized dosing in rodent drug discrimination paradigms
- Dose-response curve generation with reduced variability
- Chronic administration studies (accurate daily dosing)
- Cross-tolerance investigations with other serotonergic compounds
Global Distribution & Discrete Logistics
BioSynLab operates regional distribution centers in Rotterdam (EU), London (UK), and Toronto (Canada) ensuring rapid delivery with minimal customs processing:
Shipping Configurations:
- Standard: Refrigerated (2-8°C) with gel packs, 3-5 business days
- Express: Temperature-monitored, 1-2 business days (DHL/FedEx)
- Cryogenic: Dry ice (-78°C) for bulk orders, with data loggers
- Discrete: Unmarked packaging, generic return addresses, no chemical nomenclature
