Description
Premium DPT Powder: Industrial Grade Chemical for Advanced Research Applications
Product Details Table
| Attribute | Specification |
|---|---|
| Brand | BioSynLab Research Compounds |
| Product Name | DPT (N,N-Dipropyltryptamine) |
| IUPAC Name | N-[2-(1H-indol-3-yl)ethyl]-N-propylpropan-1-amine |
| Synonyms | Dipropyltryptamine, N,N-Dipropyltryptamine, DPT Freebase |
| CAS Number | 6320-14-5 (freebase); 6320-15-6 (hydrochloride) |
| Molecular Formula | C₁₆H₂₄N₂ |
| Molecular Weight | 244.38 g/mol |
| Purity | ≥98.5% (HPLC Verified) |
| Appearance | White to Off-White Crystalline Powder |
| Form | Freebase Powder (Micronized) |
| Particle Size | 40-80 microns |
| Storage | -20°C, Argon Atmosphere, Desiccated |
| Packaging | Amber Borosilicate Vials with PTFE Seals |
| Available Quantities | 250mg, 500mg, 1g, 5g, 10g |
| Documentation | COA, HPLC, NMR, MSDS, Stability Data |
| Shipping | Cryogenic Packaging Available |
| Origin | EU/GMP Certified Laboratory |
DPT Powder (N,N-Dipropyltryptamine) | Classic Tryptamine Research Compound | BioSynLab
BioSynLab presents pharmaceutical-grade DPT (N,N-dipropyltryptamine) powder for advanced neuropharmacological research and comparative tryptamine studies. As a homolog of DMT featuring dipropyl substitution on the side-chain nitrogen, DPT serves as a critical reference compound for investigating N-alkyl chain length effects on serotonin receptor pharmacology, duration of action, and structure-activity relationships within the classic psychedelic scaffold.
Chemical Architecture & Homologous Relationships
N,N-Dipropyltryptamine represents the third member of the N,N-dialkyltryptamine homologous series, positioned between DMT (dimethyl) and DET (diethyl) in terms of alkyl chain length:
Structural Features:
- Indole Nucleus: Maintains the essential tryptophan-derived chromophore with unsubstituted 4-, 5-, 6-, and 7-positions
- Ethylamine Side Chain: Standard C₂ linker between indole C-3 and terminal nitrogen
- N,N-Dipropyl Substitution: Two propyl groups (C₃H₇) on the side-chain nitrogen, creating increased steric bulk and lipophilicity vs. DMT
Physicochemical Properties:
- Molecular weight: 244.38 g/mol (28 mass units > DMT, 28 mass units < DET)
- Calculated LogP: 3.8 (moderate lipophilicity, increased vs. DMT)
- pKa (tertiary amine): ~8.7 (protonated at physiological pH)
- Melting point: 88-92°C (freebase)
- Boiling point: 180-190°C at 0.5 mmHg
- Chirality: Achiral (no stereocenters)
Homologous Series Comparison:
| Compound | N-Substituents | MW | LogP | Duration* |
|---|---|---|---|---|
| DMT | Dimethyl (C₁) | 232.28 | 2.8 | 15-30 min |
| DPT | Dipropyl (C₃) | 244.38 | 3.8 | 2-4 hours |
| DET | Diethyl (C₂) | 260.38 | 3.3 | 2-4 hours |
*Approximate research parameters
Analytical Characterization & Quality Verification
Each BioSynLab DPT production batch undergoes comprehensive analytical profiling:
Chromatographic Analysis:
- HPLC-UV (280nm): ≥98.5% purity by peak area normalization
- Related substances: <1.5% total impurities, <0.5% single impurity
- Chiral HPLC: Confirms achirality (no enantiomers present)
- Residual solvents: Meets ICH Q3C (methanol, ethanol, ethyl acetate, hexane)
Spectroscopic Confirmation:
- ¹H NMR (500MHz, CDCl₃):
- Indole N-H: δ 8.12 (br s, 1H)
- Aromatic H-4, H-5, H-6, H-7: δ 6.95-7.50 (m, 4H)
- Indole H-2: δ 7.05 (s, 1H)
- Side chain CH₂: δ 2.95 (t, 2H, J=7.5Hz, α-CH₂)
- Side chain CH₂: δ 2.75 (t, 2H, J=7.5Hz, β-CH₂)
- N-CH₂: δ 2.55 (t, 4H, J=7.8Hz, propyl α-CH₂)
- Propyl CH₂: δ 1.55 (sextet, 4H, J=7.5Hz)
- Propyl CH₃: δ 0.92 (t, 6H, J=7.4Hz)
- ¹³C NMR (125MHz): 16 distinct carbon signals
- FTIR: N-H stretch (3400 cm⁻¹), aromatic C-H (3050 cm⁻¹), aliphatic C-H (2850-2960 cm⁻¹)
- UV-Vis: λmax 222nm, 275nm, 280nm (characteristic tryptophan spectrum)
- LC-MS/MS: [M+H]⁺ at m/z 245.2, major fragments at m/z 144 (indole-CH=CH₂), 130 (indole-CH₃)
Physical Testing:
- Melting point: 88-92°C (confirms identity, freebase form)
- Water content: <0.5% (Karl Fischer)
- Heavy metals: <10 ppm (ICP-MS)
- Loss on drying: <0.5% (105°C, 3 hours)
Powder Engineering & Laboratory Handling
Our micronized DPT powder (40-80μm) optimizes research applications:
Solubility Profile:
- Chloroform: ≥100 mg/mL (excellent)
- Dichloromethane: ≥80 mg/mL (excellent)
- Methanol: ≥60 mg/mL (very good)
- Ethanol: ≥50 mg/mL (good)
- Acetonitrile: ≥40 mg/mL (good)
- Dimethyl sulfoxide (DMSO): ≥80 mg/mL (very good)
- Aqueous buffers (pH 7.4): <2 mg/mL (requires co-solvent)
Recommended Stock Solutions:
- 10 mM DMSO stock: Dissolve 2.44mg in 1mL anhydrous DMSO
- Storage: -80°C in aliquoted portions under argon
- Working solutions: Prepare fresh daily; aqueous solutions unstable beyond 24 hours
Handling Precautions:
- Anti-static measures: Grounded equipment, ionizing blowers (fine powder generates static)
- Light protection: Amber glassware or aluminum foil (photosensitive)
- Oxygen exclusion: Argon or nitrogen atmosphere for long-term storage
- Temperature control: Maintain frozen until use; thaw only required quantity
Research Applications & Scientific Significance
DPT powder serves critical functions in multiple research disciplines:
Neuropharmacology:
- 5-HT1A/5-HT2A receptor binding affinity comparisons (DMT vs. DPT vs. DET)
- N-alkyl chain length SAR (structure-activity relationships)
- Receptor subtype selectivity (5-HT1A partial agonist, 5-HT2A full agonist)
- Functional selectivity (G-protein coupling vs. β-arrestin recruitment)
Pharmacokinetic Research:
- Duration of action modeling (propyl groups extend vs. methyl)
- Metabolic stability (CYP2D6 substrate, N-dealkylation pathway)
- Blood-brain barrier penetration (LogP correlation studies)
- Plasma protein binding (determination via equilibrium dialysis)
Behavioral Neuroscience:
- Drug discrimination paradigms (stimulus generalization to other tryptamines)
- Locomotor activity assays (rodent open field, automated tracking)
- Prepulse inhibition (PPI) disruption (sensorimotor gating)
- Head-twitch response quantification (5-HT2A mediated)
Forensic & Analytical Chemistry:
- GC-MS method development (requires derivatization for optimal peak shape)
- LC-MS/MS forensic libraries (retention time databases)
- Distinguishing DPT from DMT/DET (chromatographic resolution)
- Isotopic analysis (synthetic vs. natural origin differentiation)
Historical & Comparative Research:
- Psychopharmacology literature reference standard
- Clinical research archives (1960s-1970s studies)
- Religious/ritual use anthropological studies (Santo Daime, UDV comparisons)
- Controlled substance scheduling rationale investigations
Global Distribution & Licensed Research Supply
BioSynLab operates strict verification protocols for DPT distribution:
Eligibility Requirements:
- DEA Schedule I research registration (USA)
- Home Office controlled drug license (UK)
- Competent authority authorization (EU member states)
- Institutional verification (university, government lab, pharmaceutical research)
Packaging & Shipping:
- Cryogenic packaging: -20°C with phase-change materials
- Discrete outer packaging: Unmarked, generic return addresses
- Documentation: Import/export permits, customs declarations prepared
- Courier options: DHL Express, FedEx International Priority, UPS Worldwide
Service Coverage (Licensed Institutions Only):
