Description

Premium Industrial Grade MK-677 Powder (Ibutamoren/Nutrobal) – Comprehensive Product Guide

 

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Product Details Table

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MK-677 Powder (Ibutamoren Mesylate/Nutrobal/Istobal) | Growth Hormone Secretagogue Research Compound | BioSynLab

BioSynLab presents pharmaceutical-grade MK-677 (Ibutamoren mesylate) for advanced endocrinological research and growth hormone secretagogue studies. Also known as Nutrobal or Istobal, this orally active non-peptide ghrelin receptor agonist serves as a critical research tool for investigating growth hormone (GH) release mechanisms, insulin-like growth factor 1 (IGF-1) modulation, and metabolic pathway research in laboratory settings.

Chemical Architecture & Mechanism of Action

MK-677 (Ibutamoren) is a spiropiperidine derivative that functions as a potent, orally bioavailable growth hormone secretagogue:

Structural Features:

• Spiropiperidine Core: Bicyclic structure providing metabolic stability and oral bioavailability
• Biphenylmethyl Substituent: Enhances lipophilicity and membrane permeability
• Carboxamide Functionality: Key pharmacophore for ghrelin receptor (GHS-R1a) binding
• Mesylate Salt Form: Methanesulfonate counterion ensuring crystalline stability and enhanced solubility

Mechanism of Action:

• Ghrelin Receptor Agonist: Mimics endogenous ghrelin (growth hormone-releasing peptide)
• GHS-R1a Activation: Stimulates pituitary growth hormone release
• Somatostatin Inhibition: Suppresses somatostatin-mediated negative feedback
• Oral Bioavailability: Unlike peptide GH secretagogues (GHRP-6, Ipamorelin), MK-677 is orally active

Physicochemical Properties:

• Molecular weight: 624.77 g/mol (mesylate salt)
• Calculated LogP: 3.2 (moderate lipophilicity)
• pKa (piperidine N): ~9.5 (protonated at physiological pH)
• Melting point: 156-162°C (mesylate salt)
• Chirality: Single enantiomer (chiral center at spiro junction)

Analytical Characterization & Quality Verification

Each BioSynLab MK-677 batch undergoes comprehensive analytical profiling:

Chromatographic Analysis:

• HPLC-UV (220nm): ≥99.0% purity by area normalization
• Chiral HPLC: Enantiomeric purity confirmation (>99% ee)
• Related substances: <1.0% total impurities
• Residual solvents: Meets ICH Q3C (methanol, ethanol, acetonitrile, dichloromethane)

Mass Spectrometry:

• LC-MS/MS: [M+H]⁺ at m/z 529.4 (freebase), fragmentation pattern matching reference
• High-Resolution MS: Exact mass confirmation <5 ppm deviation

Nuclear Magnetic Resonance (NMR):

• ¹H NMR (500MHz, DMSO-d₆):
  • Aromatic protons: δ 7.15-7.45 (m, 9H)
  • Spiropiperidine CH₂: δ 2.8-3.4 (m, 8H)
  • Amide NH: δ 8.12 (br s, 1H)
  • Mesylate CH₃: δ 2.38 (s, 3H)
• ¹³C NMR (125MHz): 28 distinct carbon signals
• FTIR: Amide C=O (1650 cm⁻¹), aromatic C-H (3050 cm⁻¹), S=O (1160 cm⁻¹)

Physical Testing:

• Water content: <0.5% (Karl Fischer)
• Heavy metals: <10 ppm (ICP-MS)
• Specific rotation: [α]²⁰D = -12° to -16° (c=1, methanol)
• Residue on ignition: <0.1%

Powder Engineering & Research Handling

Our micronized MK-677 mesylate powder (20-50μm) optimizes research applications:

Solubility Profile:

• Dimethyl sulfoxide (DMSO): ≥100 mg/mL (excellent)
• Methanol: ≥80 mg/mL (very good)
• Ethanol: ≥60 mg/mL (good)
• Water: ~10 mg/mL (limited, requires warming)
• Phosphate-buffered saline (PBS): ~5 mg/mL (with sonication)

Recommended Stock Solutions:

• 10 mM DMSO stock: Dissolve 6.25mg in 1mL anhydrous DMSO
• Storage: -20°C in aliquoted portions
• Working solutions: Prepare fresh daily in aqueous buffers

Handling Precautions:

• Light protection: Amber glassware or foil wrapping (photosensitive)
• Temperature control: Maintain frozen until use
• Desiccation: Keep desiccated to prevent hydrolysis of mesylate salt

Research Applications & Scientific Significance

MK-677 serves critical functions in multiple research disciplines:

Endocrinology & Metabolism:

• Growth hormone release assays (pituitary cell cultures)
• IGF-1 induction studies (liver cell models)
• Ghrelin receptor signaling (GHS-R1a pathway mapping)
• Somatostatin modulation (hypothalamic feedback mechanisms)

Musculoskeletal Research:

• Bone density and mineralization studies
• Muscle protein synthesis assays
• Nitrogen retention investigations
• Tissue repair and regeneration models

Metabolic Studies:

• Appetite stimulation mechanisms (hypothalamic neuropeptide Y)
• Glucose homeostasis (insulin sensitivity research)
• Lipid metabolism (fat oxidation pathways)
• Energy expenditure quantification

Aging & Longevity Research:

• Growth hormone deficiency models
• Sarcopenia (age-related muscle loss) studies
• Osteoporosis research
• Cognitive aging (neuroprotective effects)

Pharmacokinetic Research:

• Oral bioavailability comparisons (vs. injectable GH)
• Plasma half-life determination (~4-6 hours in humans)
• Metabolic stability (CYP450 profiling)
• Tissue distribution studies

Global Distribution & Discrete Procurement

BioSynLab provides secure, compliant distribution:

Packaging Specifications:

• Primary: Amber Type I borosilicate glass
• Secondary: Argon-flushed aluminized barrier pouch
• Tertiary: Discrete unmarked shipping containers

Shipping Options:

• Standard: Ambient temperature, 5-7 days
• Refrigerated: 2-8°C for extended stability
• Express: Tracked courier, 2-3 days
• Discrete: No product identifiers, generic return addresses

Service Coverage:

United Kingdom: London, Manchester, Birmingham, Leeds, Glasgow, Liverpool, Sheffield, Bristol, Edinburgh, Cardiff, Belfast, Nottingham, Leicester.

European Union: Berlin, Hamburg, Munich, Cologne, Frankfurt, Amsterdam, Rotterdam, Paris, Lyon, Barcelona, Madrid, Rome, Milan, Vienna, Brussels, Prague, Warsaw.

North America: New York, Los Angeles, Chicago, Houston, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Toronto, Vancouver.