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SR-9009 (Stenabolic) Capsules | REV-ERB Agonist for Metabolic & Circadian Research | BioSynLab

BioSynLab presents pharmaceutical-grade SR-9009 (Stenabolic) in convenient capsule formulation for advanced metabolic research, circadian rhythm studies, and exercise mimetics investigation. As a potent REV-ERBα/β agonist, SR-9009 serves as a critical research tool for investigating nuclear receptor-mediated metabolism, mitochondrial biogenesis, and chronobiological regulation in laboratory settings.

Chemical Architecture & REV-ERB Mechanism

SR-9009 (Stenabolic) is a synthetic imidazopyridine derivative that functions as a high-affinity agonist for REV-ERB nuclear receptors:

Structural Features:

• Imidazo[4,5-b]pyridine Core: Fused bicyclic heterocycle providing nuclear receptor binding scaffold
• 4-Chlorobenzyl Substituent: Lipophilic aromatic group enhancing cell membrane permeability
• Trifluoromethyl Phenyl Ring: Electron-withdrawing groups optimizing binding affinity
• Trifluoro-2-hydroxypropyl Moiety: Unique substitution conferring metabolic stability

Mechanism of Action:

• REV-ERBα/β Agonist: Binds nuclear receptors NR1D1/REV-ERBα and NR1D2/REV-ERBβ
• Circadian Modulation: Regulates BMAL1/CLOCK transcriptional feedback loop
• Metabolic Effects: Influences glucose metabolism, lipid homeostasis, and mitochondrial function
• Exercise Mimetics: Recruits oxidative muscle fibers and increases endurance capacity

Physicochemical Properties:

• Molecular weight: 437.94 g/mol
• Calculated LogP: 4.2 (highly lipophilic)
• pKa: Non-ionizable (neutral molecule)
• Melting point: 120-125°C (crystalline solid)
• Chirality: Achiral (no stereocenters)

Capsule Formulation & Pharmaceutical Engineering

Our SR-9009 capsules utilize advanced formulation technology:

Excipient Composition:

• Active Pharmaceutical Ingredient: SR-9009 – 10mg, 20mg, or 30mg
• Diluent: Microcrystalline cellulose (Avicel PH-102) – 120-250mg
• Glidant: Silicon dioxide (Aerosil) – 2-5mg
• Lubricant: Magnesium stearate – 2-3mg

Capsule Specifications:

Quality Attributes:

• Content uniformity: RSD <6% (USP <905>)
• Weight variation: Meets USP <905> criteria
• Disintegration: <30 minutes (USP <701>)
• Dissolution: >80% in 45 minutes (simulated gastric fluid)

Packaging Options:

• HDPE bottles: 30, 60, 90 count with desiccant canister
• Blister packs: 10 capsules per sheet, child-resistant
• Bulk packaging: 500, 1000 count for institutional orders

Analytical Characterization & Quality Verification

Each BioSynLab SR-9009 batch undergoes comprehensive analytical profiling:

Chromatographic Analysis:

• HPLC-UV (254nm): ≥99.0% purity by area normalization
• Related substances: <1.0% total impurities
• Residual solvents: Meets ICH Q3C (methanol, ethanol, acetonitrile, hexane)

Mass Spectrometry:

• LC-MS/MS: [M+H]⁺ at m/z 438.1, characteristic fragmentation pattern
• High-Resolution MS: Exact mass confirmation <5 ppm deviation

Nuclear Magnetic Resonance (NMR):

• ¹H NMR (500MHz, DMSO-d₆):
  • Aromatic protons: δ 6.9-8.2 (m, 8H)
  • Benzyl CH₂: δ 4.35 (s, 2H)
  • Hydroxyl: δ 5.85 (br s, 1H)
  • CF₃: δ Not observed (¹⁹F NMR)
• ¹⁹F NMR: Two signals at δ -62.3 and -63.1 ppm
• ¹³C NMR (125MHz): 20 distinct carbon signals
• FTIR: O-H (3400 cm⁻¹), C=N (1620 cm⁻¹), C-F (1120 cm⁻¹)

Physical Testing:

• Water content: <0.5% (Karl Fischer)
• Heavy metals: <10 ppm (ICP-MS)
• Residue on ignition: <0.1%

Research Applications & Scientific Significance

SR-9009 capsules serve critical functions in multiple research disciplines:

Circadian Biology:

• REV-ERB-mediated clock gene regulation
• BMAL1/CLOCK transcriptional feedback studies
• Circadian rhythm modulation in metabolic tissues
• Sleep-wake cycle research

Metabolic Research:

• Glucose homeostasis and insulin sensitivity
• Lipid metabolism and cholesterol regulation
• Mitochondrial biogenesis in skeletal muscle
• Brown adipose tissue activation

Exercise Physiology:

• Endurance capacity enhancement models
• Oxidative muscle fiber recruitment
• Exercise mimetics without physical activity
• Fatigue resistance studies

Inflammation & Immunity:

• REV-ERB-mediated anti-inflammatory effects
• Macrophage polarization studies
• Cytokine production modulation
• Autoimmune disease models

Cardiovascular Research:

• Atherosclerosis progression studies
• Vascular inflammation models
• Cardiac metabolism regulation
• Hypertension research

Pharmacokinetic Studies:

• Poor oral bioavailability (~2-4%) due to extensive first-pass metabolism
• Alternative formulations research (sublingual, transdermal, injectable)
• SR-9011 comparison (improved analog)

Global Distribution & Discrete Procurement

BioSynLab provides secure, compliant distribution:

Packaging Specifications:

• Primary: Hard gelatin capsules in HDPE bottles or blister packs
• Secondary: Tamper-evident seals, desiccant chambers
• Tertiary: Discrete unmarked shipping containers

Shipping Options:

• Standard: Ambient temperature, 5-7 days
• Express: Tracked courier, 2-3 days
• Discrete: No product identifiers, generic return addresses

Service Coverage:

United Kingdom: London, Manchester, Birmingham, Leeds, Glasgow, Liverpool, Sheffield, Bristol, Edinburgh, Cardiff, Belfast, Nottingham, Leicester.

European Union: Berlin, Hamburg, Munich, Cologne, Frankfurt, Amsterdam, Rotterdam, Paris, Lyon, Barcelona, Madrid, Rome, Milan, Vienna, Brussels, Prague, Warsaw.

North America: New York, Los Angeles, Chicago, Houston, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Toronto, Vancouver.